Identification of O-glycosylated proteins that are aberrantly excreted in the urine of patients with early stage ovarian cancer

• Published in: International journal of molecular sciences Vol. 14; no. 4; pp. 7923 - 7931
• Main Authors: Mu, Alan Kang-Wai, Lim, Boon-Kiong, Hashim, Onn Haji, Shuib, Adawiyah Suriza
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2013; Molecular Diversity Preservation International (MDPI)
• Subjects: Aged; Aged, 80 and over; biomarker; Biomarkers, Tumor - urine; champedak galactose binding lectin; Clusterin - urine; Female; Glycoproteins - urine; Glycosylation; Humans; Kininogens - urine; Middle Aged; Neoplasm Proteins - urine; Neoplasm Staging; O-glycan; Ovarian cancer; Ovarian Neoplasms - pathology; Ovarian Neoplasms - urine; proteomics; two-dimensional gel electrophoresis; urine

Cancer is known to induce or alter the O-glycosylation of selective proteins that may eventually be excreted in the patients' urine. The present study was performed to identify O-glycosylated proteins that are aberrantly excreted in the urine of patients with early stage ovarian cancer (OCa). T...