Secreted Protein Acidic and Rich in Cysteine as A Regeneration Factor: Beyond the Tissue Repair

• Published in: Life (Basel, Switzerland) Vol. 11; no. 1; p. 38
• Main Authors: Ghanemi, Abdelaziz, Yoshioka, Mayumi, St-Amand, Jonny
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.01.2021; MDPI
• Subjects: Adaptation; Aging; Bioengineering; Bones; Cancer; Collagen; Cysteine; Diabetes mellitus; Energy; Exercise; Extracellular matrix; Homeostasis; Inflammation; Metabolism; Musculoskeletal system; Obesity; Opinion; Osteonectin; Osteoporosis; Oxidative stress; Physical activity; Physical fitness; Physiology; Proteins; Regeneration; Repair; Roles; Sarcopenia; secreted protein acidic and rich in cysteine; Tissue engineering; Tissues; homeostasis; regeneration; secreted protein acidic and rich in cysteine
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life11010038

Diverse pathologies (inflammation, tissues injuries, cancer, etc.) and physiological conditions (obesity, physical activity, etc.) induce the expression/secretion of the matricellular protein, secrete protein acidic and rich in cysteine (SPARC). SPARC contributes to the creation of an environment that is suitable for tissue regeneration through a variety of roles, including metabolic homeostasis, inflammation reduction, extracellular matrix remodeling and collagen maturation. Such a homeostatic environment optimizes tissue regeneration and improves tissues' repair ability. These properties that SPARC has within the regeneration contexts could have a variety of applications, such as in obesity, cancer, sarcopenia, diabetes and bioengineering.