Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions

• Published in: Genes & development Vol. 25; no. 3; pp. 214 - 219
• Main Authors: Reddy, Bharat D, Wang, Yu, Niu, Lifang, Higuchi, Emily C, Marguerat, Samuel B, Bähler, Jürg, Smith, Gerald R, Jia, Songtao
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.02.2011
• Subjects: Centromere - metabolism; Heterochromatin - metabolism; Histone Acetyltransferases - metabolism; Research Communication; RNA Interference - physiology; RNA Polymerase II - metabolism; Schizosaccharomyces - enzymology; Schizosaccharomyces - genetics; Schizosaccharomyces pombe; Schizosaccharomyces pombe Proteins - genetics; Schizosaccharomyces pombe Proteins - metabolism

In Schizosaccharomyces pombe, the RNAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregation, and repression of pericentric meiotic recombination. Here we demonstrate that, when the activity of the histone H3 Lys 14 (H3K14) acetyltransferase Mst2 is elim...