Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions

In Schizosaccharomyces pombe, the RNAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregation, and repression of pericentric meiotic recombination. Here we demonstrate that, when the activity of the histone H3 Lys 14 (H3K14) acetyltransferase Mst2 is elim...

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Published inGenes & development Vol. 25; no. 3; pp. 214 - 219
Main Authors Reddy, Bharat D, Wang, Yu, Niu, Lifang, Higuchi, Emily C, Marguerat, Samuel B, Bähler, Jürg, Smith, Gerald R, Jia, Songtao
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.02.2011
Subjects
Centromere - metabolism
Heterochromatin - metabolism
Histone Acetyltransferases - metabolism
Research Communication
RNA Interference - physiology
RNA Polymerase II - metabolism
Schizosaccharomyces - enzymology
Schizosaccharomyces - genetics
Schizosaccharomyces pombe
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
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Summary:In Schizosaccharomyces pombe, the RNAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregation, and repression of pericentric meiotic recombination. Here we demonstrate that, when the activity of the histone H3 Lys 14 (H3K14) acetyltransferase Mst2 is eliminated, the RNAi machinery is no longer required for pericentric heterochromatin functions. We further reveal that reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heterochromatin in the absence of RNAi.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1993611