The Effectiveness of 23-valent Pneumococcal Polysaccharide Vaccine on Elderly Colorectal Cancer Long-Term Survivors: A population-based exact-matched cohort study

• Published in: Human vaccines & immunotherapeutics Vol. 20; no. 1; p. 2350093
• Main Authors: Lee, Moon-Sing, Chiou, Shin-Yi, Hsu, Feng-Chun, Lin, Hon-Yi, Li, Chung-Yi, Hung, Shih-Kai, Yu, Ben-Hui, Wu, Chin-Chia, Chen, Liang-Cheng, Chew, Chia-Hui, Chiou, Wen-Yen
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2024; Taylor & Francis Group
• Subjects: Aged; Aged, 80 and over; Cancer Survivors - statistics & numerical data; Cohort Studies; colorectal cancer; Colorectal Neoplasms - mortality; Female; hospitalization; Hospitalization - statistics & numerical data; Humans; Incidence; Male; Middle Aged; Pneumococcal; Pneumococcal Infections - epidemiology; Pneumococcal Infections - mortality; Pneumococcal Infections - prevention & control; Pneumococcal polysaccharide vaccine; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - immunology; pneumonia; Registries; Survival Rate; survivor; Taiwan - epidemiology; Vaccination; Vaccine Efficacy; Taiwan; colorectal cancer; Pneumococcal polysaccharide vaccine; hospitalization; pneumonia; survivor
• ISSN: 2164-5515; 2164-554X
• DOI: 10.1080/21645515.2024.2350093

Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000-2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 (  = .391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.