Human Herpesvirus-6: A Short Review of Its Biological Behavior

HHV-6 shows a widespread distribution with life-long persistence. The virus is frequently reactivated, yet remains clinically inapparent unless the patient is immunodeficient in some way. Even then, HHV-6 reactivation may simply enhance the pathogenicity of other viruses or existing autoimmune disor...

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Bibliographic Details
Published inIntervirology Vol. 46; no. 5; pp. 257 - 269
Main Authors Krueger, Gerhard R.F., Ablashi, Dharam V.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 2003
Subjects
Adult
Cell Line
Child
Child, Preschool
Herpesvirus 6, Human - genetics
Herpesvirus 6, Human - pathogenicity
Herpesvirus 6, Human - physiology
Human herpesvirus 6
Humans
Infant
Mini Review
Roseolovirus Infections - epidemiology
Roseolovirus Infections - physiopathology
Roseolovirus Infections - virology
Molecular biology
Epidemiology
Clinical pathology
HHV-6
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Summary:HHV-6 shows a widespread distribution with life-long persistence. The virus is frequently reactivated, yet remains clinically inapparent unless the patient is immunodeficient in some way. Even then, HHV-6 reactivation may simply enhance the pathogenicity of other viruses or existing autoimmune disorders rather than becoming a pathogen itself. Future clinical studies need to focus on such indirect viral influences mediated through molecular mimicry and interference with cell receptor expression, and cytokine and chemokine network regulation. Nevertheless, such disturbances may afford therapeutic intervention to disrupt herpesvirus interference and improve certain disease processes. There are only a few diseases for which an immediate causal relationship to HHV-6 infection has been suggested.
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ISSN:0300-5526
1423-0100
DOI:10.1159/000073205