The Roles of MicroRNA in Lung Cancer

• Published in: International journal of molecular sciences Vol. 20; no. 7; p. 1611
• Main Authors: Wu, Kuan-Li, Tsai, Ying-Ming, Lien, Chi-Tun, Kuo, Po-Lin, Hung, Jen-Yu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.03.2019; MDPI
• Subjects: Animals; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell cycle; Cell growth; Deoxyribonucleic acid; DNA; Enzymes; Epidermal growth factor; Epigenetics; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Humans; Kinases; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Medical prognosis; Metastasis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Mutation; Prognosis; Proteins; Review; RNA polymerase; Senescence; Telomerase; lung cancer; microRNA
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20071611

Lung cancer is the most devastating malignancy in the world. Beyond genetic research, epigenomic studies—especially investigations of microRNAs—have grown rapidly in quantity and quality in the past decade. This has enriched our understanding about basic cancer biology and lit up the opportunities for potential therapeutic development. In this review, we summarize the involvement of microRNAs in lung cancer carcinogenesis and behavior, by illustrating the relationship to each cancer hallmark capability, and in addition, we briefly describe the clinical applications of microRNAs in lung cancer diagnosis and prognosis. Finally, we discuss the potential therapeutic use of microRNAs in lung cancer.