Autosomal recessive spastic ataxia of Charlevoix-Saguenay in two unrelated Turkish families

Autosomal recessive spastic ataxia of Charlevoix-Saguenay is an early onset form of hereditary spastic paraplegia with a peculiar clinical presentation. In addition to cerebellar findings which manifest first with ataxic gait in early life and spasticity, on an evolutionary basis, there is axonal ne...

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Published inNeuropediatrics Vol. 32; no. 3; p. 142
Main Authors Gücüyener, K, Ozgül, K, Paternotte, C, Erdem, H, Prud'homme, J F, Ozgüç, M, Topaloğlu, H
Format Journal Article
LanguageEnglish
Published Germany 01.06.2001
Subjects
Adolescent
Adult
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosomes, Human, Pair 13
Consanguinity
Female
Genes, Recessive - genetics
Genetic Markers - genetics
Heat-Shock Proteins - genetics
Humans
Male
Neurologic Examination
Pedigree
Spastic Paraplegia, Hereditary - diagnosis
Spastic Paraplegia, Hereditary - genetics
Spinocerebellar Ataxias - diagnosis
Spinocerebellar Ataxias - genetics
Turkey
Turkey
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Summary:Autosomal recessive spastic ataxia of Charlevoix-Saguenay is an early onset form of hereditary spastic paraplegia with a peculiar clinical presentation. In addition to cerebellar findings which manifest first with ataxic gait in early life and spasticity, on an evolutionary basis, there is axonal neuropathy, prominent myelinated fibers in the optic fundus, and evidence of cerebellar atrophy that can be detected by cranial MRI. Intelligence is usually normal, however lower IQs have also been documented. This disorder mainly originates from the Charlevoix-Saguenay region of Quebec. Here, we report two Turkish families linked to the disease locus on chromosome 13 q12. There was homozygosity and segregation of disease haplotypes in both families. This form of spastic ataxia may be more common than originally presumed.
ISSN:0174-304X
DOI:10.1055/s-2001-16616