SIMILARITY OF LIPID INCLUSIONS IN EXPERIMENTAL ATHEROSCLEROSIS OF RABBITS TO THOSE OF HUMANS

A comparative study was made on lipid inclusions of human and rabbits. Atherosclerotic lesions were produced in rabbits fed 0.67% cholesterol for seven months. The loci of the inclusions produced in tissue, three-dimensional configuration, crystallographic characteristics, physical properties and ch...

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Published inACTA HISTOCHEMICA ET CYTOCHEMICA Vol. 11; no. 3; pp. 369 - 383
Main Authors HATA, YOSHIYA, SHIGEMATSU, HIROSHI, TSUSHIMA, MOTOO, AIHARA, KAZUO, MIYAZAKI, KAZUE
Format Journal Article
LanguageEnglish
Published Sendai JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 01.01.1978
Japan Science and Technology Agency
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Summary:A comparative study was made on lipid inclusions of human and rabbits. Atherosclerotic lesions were produced in rabbits fed 0.67% cholesterol for seven months. The loci of the inclusions produced in tissue, three-dimensional configuration, crystallographic characteristics, physical properties and chemical compositions were compared, and found to be similar and even identical between man and rabbit. The lipid inclusions were thus presumed to be formed in arterial tissues by a cellular metabolism common to man and rabbit, and shaped by a physico-chemical effect independent of difference in species. Hence, rabbits are found usable as a model for the study of lipid inclusions in experimentally induced atherosclerosis.
ISSN:0044-5991
1347-5800
DOI:10.1267/ahc.11.369