Prognostic Impact of Genetic Variants of MECP2 and TIRAP on Clinical Outcomes of Systemic Lupus Erythematosus with and without Nephritis

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 9; p. 1378
• Main Authors: Tayel, Safaa I, Muharram, Nashwa M, Fotoh, Dina S, Elbarbary, Hany S, Abd-Elhafiz, Huda I, El-Masry, Eman A, Taha, Ahmed E, Soliman, Shimaa E
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.09.2021; MDPI
• Subjects: Adult; Alleles; Antibodies; arthritis; Autoimmune diseases; Blood Sedimentation; Classification; Clinical outcomes; Creatinine; Disease; DNA methylation; Female; Gene expression; Gene polymorphism; Genetic diversity; Genetic Predisposition to Disease; Genetic Variation; Genotyping; Helper cells; Hematuria; Humans; Inflammatory diseases; Kidneys; Laboratories; Lupus; Lupus nephritis; Lupus Nephritis - genetics; Lymphocytes T; MECP; MeCP2 protein; Medical prognosis; Membrane Glycoproteins - genetics; Methyl-CpG binding protein; Methyl-CpG-Binding Protein 2 - genetics; Nephritis; Nephrology; Patients; Polymorphism, Single Nucleotide - genetics; Population studies; Prognosis; Proteins; Receptors, Interleukin-1 - genetics; Rheumatology; Systemic lupus erythematosus; TIRAP; Treatment Outcome; Urinalysis; Urine; Vitamin A; nephritis; MECP; systemic lupus erythematosus; arthritis; TIRAP
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom11091378

Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with a growing prevalence in many populations. Few studies have examined genetic predisposition to SLE, so we aimed to examine the clinical impact of the genetic polymorphisms rs2734647and rs8177374 on the outcomes and therapeutic precision of SLE with and without nephritis. This study included 110 SLE patients-divided into 63 with lupus nephritis (LN), and 47 without nephritis-and 100 controls. Laboratory measurements including CRP, ESR, ACR, CBC, anti-ds-DNA, vitamin A, C3, and C4 were carried out, along with genotyping of rs2734647and rs8177374 by real-time PCR and sequencing. Treg %, vitamin A, C3, and C4 were lower, whereas Th17 % was higher, in patients vs. controls ( < 0.001). The T allele of rs2734647 was higher in LN than in non-nephritis and control subjects. Moreover, the T allele of rs8177374 was higher in LN than in non-nephritis and control subjects. The and genes could play a role in predisposition to SLE, and can also predict disease progress to nephritis, helping to personalize medicine.