Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences

In a recent study, 1373 highly conserved non-coding elements (CNEs) were detected by aligning the human and Takifugu rubripes (Fugu) genomes. The remarkable degree of sequence conservation in CNEs compared with their surroundings suggested comparing the base composition within CNEs with their 5′ and...

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Published inTrends in genetics Vol. 21; no. 8; pp. 436 - 440
Main Authors Walter, Klaudia, Abnizova, Irina, Elgar, Greg, Gilks, Walter R.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.08.2005
Elsevier Science
Subjects
Animals
Base Composition
Biological and medical sciences
Conserved Sequence
DNA - chemistry
DNA - genetics
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
Molecular and cellular biology
Takifugu - genetics
Vertebrates - genetics
Frequency
Genetics
Non coding sequence
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Summary:In a recent study, 1373 highly conserved non-coding elements (CNEs) were detected by aligning the human and Takifugu rubripes (Fugu) genomes. The remarkable degree of sequence conservation in CNEs compared with their surroundings suggested comparing the base composition within CNEs with their 5′ and 3′ flanking regions. The analysis reveals a novel, sharp and distinct signal of nucleotide frequency bias precisely at the border between CNEs and flanking regions.
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ISSN:0168-9525
DOI:10.1016/j.tig.2005.06.003