Interferon Regulatory Factor 5 ( IRF5 ) Gene Haplotypes Are Associated with Premature Coronary Artery Disease. Association of the IRF5 Polymorphisms with Cardiometabolic Parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 3; p. 443
• Main Authors: Posadas-Sánchez, Rosalinda, Cardoso-Saldaña, Guillermo, Fragoso, José Manuel, Vargas-Alarcón, Gilberto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.03.2021; MDPI
• Subjects: Abdomen; Adiponectin; Apolipoprotein B; Apolipoproteins; Arteriosclerosis; Aspartate aminotransferase; Atherosclerosis; Calcification; cardiometabolic parameters; Cardiovascular disease; Cholesterol; Coronary artery; Coronary vessels; Cytokines; Gene polymorphism; Genealogy; genetic association; Haplotypes; Health risk assessment; Heart attacks; Heart diseases; High density lipoprotein; Hypertriglyceridemia; Hyperuricemia; Hypoalphalipoproteinemia; Hypothyroidism; Inflammation; Interferon; Interferon regulatory factor; interferon regulatory factor 5; Interleukin 15; Interleukin 6; Lifestyles; Low density lipoprotein; Magnesium; polymorphisms; premature coronary artery disease; Triglycerides; Tumor necrosis factor-α; United States > US; premature coronary artery disease; genetic association; interferon regulatory factor 5; cardiometabolic parameters; polymorphisms
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom11030443

Interferon regulatory factor 5 ( ) has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of polymorphisms with the development of premature CAD (pCAD) and cardiometabolic parameters. polymorphisms (rs1874330, rs3778754, rs3757386, rs3757385, rs3807134, rs3807135, and rs6968563) were determined in 1116 pCAD patients and 1003 controls. Polymorphism distribution was similar in patients and controls; however, the haplotype analysis showed five haplotypes with a different distribution. (OR (odds ratio) = 1.248, = 0005) and (OR = 10.73, < 0.0001) were associated with a high risk, whereas (OR = 0.155, < 0.0001), (OR = 0.108, < 0.0001), and (OR = 0.014, < 0.0001) were associated with a low risk of pCAD. Associations with aspartate aminotransferase, hypertriglyceridemia, magnesium deficiency, triglycerides/HDL-C index, LDL-C, and adiponectin levels were observed in pCAD patients. In controls, associations with hypoalphalipoproteinemia, non-HDL-C, apolipoprotein B, hyperuricemia, TNF-α, IL-6, IL-15, valvular calcification, and subclinical hypothyroidism were observed. In summary, five haplotypes were associated with pCAD, two with high risk and three with low risk. Some polymorphisms were associated with cardiometabolic parameters in pCAD patients and control.