Regulation of gene expression by alternative untranslated regions

The untranslated regions of mRNAs can determine gene expression by influencing mRNA stability and translational efficiency. Recent reports show that gene expression can be regulated by the differential use of alternative untranslated regions. Tissue-specific expression of transcripts that have diffe...

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Bibliographic Details
Published inTrends in genetics Vol. 22; no. 3; pp. 119 - 122
Main Author Hughes, Thomas A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2006
Elsevier Science
Subjects
3' Untranslated Regions - genetics
5' Untranslated Regions - genetics
Alternative Splicing
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genetics of eukaryotes. Biological and molecular evolution
Humans
Molecular and cellular biology
Gene expression
Genetics
Regulation(control)
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Summary:The untranslated regions of mRNAs can determine gene expression by influencing mRNA stability and translational efficiency. Recent reports show that gene expression can be regulated by the differential use of alternative untranslated regions. Tissue-specific expression of transcripts that have different untranslated regions (UTRs) can control protein expression enabling developmental, physiological and pathological regulation. Several examples of alternative UTRs have been characterized, including those found in AXIN2, FGF1 and BRCA1. Results from bioinformatics studies indicate that this mechanism is more common than previously appreciated.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0168-9525
DOI:10.1016/j.tig.2006.01.001