Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats

• Published in: Behavioural brain research Vol. 176; no. 2; pp. 367 - 371
• Main Authors: Deyama, Satoshi, Nakagawa, Takayuki, Kaneko, Shuji, Uehara, Takashi, Minami, Masabumi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 25.01.2007; Elsevier Science
• Subjects: Acetic Acid; Analysis of Variance; Animals; Aversion; Avoidance Learning - physiology; Bed nucleus of the stria terminalis (BST); Behavior, Animal; Behavioral psychophysiology; Biological and medical sciences; Conditioning (Psychology); Emotion; Extended amygdala; Formaldehyde; Fundamental and applied biological sciences. Psychology; Male; Neural Pathways - physiopathology; Nociceptive behavior; Pain; Pain - chemically induced; Pain - physiopathology; Pain Measurement - methods; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Reaction Time - physiology; Septal Nuclei - injuries; Septal Nuclei - physiopathology; Time Factors; Bed nucleus of the stria terminalis (BST); Nociceptive behavior; Pain; Emotion; Aversion; Extended amygdala; Nociception; Affect affectivity; Amygdala; Rat; Rodentia; Central nervous system; Basal ganglion; Emotion emotionality; Encephalon; Vertebrata; Mammalia; Animal; Perception; Behavior; Amygdaloid nucleus; Bed nucleus stria terminalis
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2006.10.021

Using a conditioned place paradigm, we examined the involvement of the bed nucleus of the stria terminalis (BST) in the negative affective component of visceral and somatic pain induced by intraperitoneal acetic acid and intraplantar formalin injections, respectively, in rats. Bilateral BST lesions suppressed both the acetic acid- and formalin-induced conditioned place aversion, suggesting the crucial role of the BST in the negative affective component of visceral and somatic pain.