The Complex Mechanism of the Salmonella typhi Biofilm Formation That Facilitates Pathogenicity: A Review

• Published in: International journal of molecular sciences Vol. 23; no. 12; p. 6462
• Main Authors: Jahan, Fahmida, Chinni, Suresh V, Samuggam, Sumitha, Reddy, Lebaka Veeranjaneya, Solayappan, Maheswaran, Su Yin, Lee
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.06.2022; MDPI
• Subjects: Antibiotic resistance; Antibiotics; Antimicrobial agents; Asymptomatic; Bacteria; Bacterial infections; Bile ducts; biofilm; Biofilms; Enzymes; Epithelium; Fever; Food contamination; Gallbladder; Gallstones; Gene expression; Human body; Humans; Immune response; Infections; Liver; Medical research; Oral administration; Oxidative stress; Pathogenicity; Pathogens; Review; Salmonella; Salmonella typhi; Typhoid; Typhoid Fever; Virulence; Pakistan; India; Salmonella typhi; gallbladder; typhoid; biofilm
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23126462

serovar Typhi ( ) is an intracellular pathogen belonging to the Enterobacteriaceae family, where biofilm (aggregation and colonization of cells) formation is one of their advantageous traits. typhi is the causative agent of typhoid fever in the human body and is exceptionally host specific. It is transmitted through the fecal-oral route by consuming contaminated food or water. This subspecies is quite intelligent to evade the innate detection and immune response of the host body, leading to systemic dissemination. Consequently, during the period of illness, the gallbladder becomes a harbor and may develop antibiotic resistance. Afterwards, they start contributing to the continuous damage of epithelium cells and make the host asymptomatic and potential carriers of this pathogen for an extended period. Statistically, almost 5% of infected people with become chronic carriers and are ready to contribute to future transmission by biofilm formation. Biofilm development is already recognized to link with pathogenicity and plays a crucial role in persistency within the human body. This review seeks to discuss some of the crucial factors related to biofilm development and its mechanism of interaction causing pathogenicity. Understanding the connections between these things will open up a new avenue for finding therapeutic approaches to combat pathogenicity.