Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

• Published in: International journal of molecular sciences Vol. 23; no. 11; p. 6031
• Main Authors: Osmakov, Dmitry I, Kalinovskii, Aleksandr P, Belozerova, Olga A, Andreev, Yaroslav A, Kozlov, Sergey A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2022; MDPI
• Subjects: anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; antioxidant; Antioxidants; Antioxidants - metabolism; Antioxidants - pharmacology; Antioxidants - therapeutic use; Chemical compounds; chemical synthesis; Cytokines; Diabetes; Enzymes; Humans; Inflammation; Inflammation - drug therapy; Kinases; lignan; Lignans; Lignans - chemistry; Lignans - pharmacology; Molecular modelling; Oxidative Stress; Pharmacology; Pharmacophores; Phosphorylation; Proteins; Review; Transcription factors; Tumor necrosis factor-TNF; chemical synthesis; anti-inflammatory; antioxidant; lignan; inflammation; oxidative stress
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23116031

Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022.