Rate effect and mismatch responses in the somatosensory system: ERP-recordings in humans

• Published in: Biological psychology Vol. 46; no. 2; pp. 125 - 142
• Main Authors: Kekoni, Jouni, Hämäläinen, Heikki, Saarinen, Mikael, Gröhn, Jutta, Reinikainen, Kalevi, Lehtokoski, Anne, Näätänen, Risto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 22.08.1997
• Subjects: Adult; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Male; MMN; Prefrontal Cortex - physiology; Rate effect; Somatosensory ERPs; Touch; Vibration; Somatosensory ERPs; Rate effect; MMN
• ISSN: 0301-0511; 1873-6246
• DOI: 10.1016/S0301-0511(97)05249-6

In the first experiment, somatosensory event-related potentials (SERPs) were recorded to tactile pulses and vibration bursts applied to the left middle finger in trains of 4–8 stimuli with 1 s intervals. In addition to the negative N140 deflection, also the positive P50, P100 and P300 waves attenuated in amplitude with stimulus repetition. These decreases were immediate, there being no marked further amplitude attenuation after the second stimulus. The locus of this rate effect appears not to be the primary SI or SII, but rather prefrontal cortices or some deeper structures. In the second experiment, vibratory stimuli of different frequencies or at different skin sites were presented using the oddball paradigm. When the deviant stimulus was a high-frequency vibration burst, it elicited a distinct N250 deflection, probably analogous to the auditory N2b. When the deviation was a change in the stimulation site, no N250 deflection but instead an extra negativity between 100–200 ms latency, probably analogous to the auditory mismatch negativity, was observed.