Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells

Colon cancer is one of the most common cancer types. Its positive correlation with general obesity has led to increasing amounts of research focusing on the role of adipokines in colon cancer development. Apelin is a peptide released by adipose tissue that could affect many cellular processes connec...

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Published inCells (Basel, Switzerland) Vol. 7; no. 8; p. 113
Main Authors Podgórska, Marta, Pietraszek-Gremplewicz, Katarzyna, Nowak, Dorota
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.08.2018
MDPI
Subjects
Actin
adipokines
Adipose tissue
Amino acids
Angiogenesis
apelin
apelin receptor
Biotechnology
Breast cancer
Carcinogenesis
Cell adhesion & migration
Cell migration
cofilin
Colon cancer
Colorectal cancer
Confocal microscopy
Cytoskeleton
Diabetes
Gastric cancer
Immunoglobulins
invasion
Lung cancer
Matrix metalloproteinase
metalloproteases
Metalloproteinase
Metastasis
migration
Motility
Obesity
Peptides
Proteins
Proteolysis
Poland
United States > US
Germany
actin
cofilin
apelin
invasion
apelin receptor
colon cancer
migration
adipokines
metalloproteases
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Summary:Colon cancer is one of the most common cancer types. Its positive correlation with general obesity has led to increasing amounts of research focusing on the role of adipokines in colon cancer development. Apelin is a peptide released by adipose tissue that could affect many cellular processes connected with carcinogenesis. In this study, we examined the role of apelin in the motility regulation of colon cancer cells. We showed that the effect of four different apelin peptides increased the ability of cancer cells to migrate and invade examined cells trough influencing migratory protrusions formation and actin cytoskeleton rearrangement. Additionally, using confocal microscopy, we noticed that apelin stimulated the proteolytic activity of cancer cells, especially increasing the level of membrane-type 1 matrix metalloprotease. Taken together, apelin increased the movement of colon cancer cells through several possible mechanisms. Moreover, better understanding the process through which apelin regulates cancer development is still necessary to the creation of novel anti-cancer therapy.
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These authors contribute equally to this paper.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells7080113