Microbiota and maintenance of skin barrier function

Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 376; no. 6596; pp. 940 - 945
Main Authors Harris-Tryon, Tamia A, Grice, Elizabeth A
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 27.05.2022
Subjects
Dehydration
Disorders
Epithelium
Host Microbial Interactions
Humans
Immune response
Microbiota
Organs
Sense organs
Skin
Skin diseases
Wound healing
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Summary:Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial to the skin's barrier function is the colonizing microbiota, which provides protection against pathogens, tunes immune responses, and fortifies the epithelium. Here we highlight recent advances in our understanding of how the microbiota mediates multiple facets of skin barrier function. We discuss recent insights into pathological host-microbiota interactions and implications for disorders of the skin and distant organs. Finally, we examine how microbiota-based mechanisms can be targeted to prevent or manage skin disorders and impaired wound healing.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.abo0693