The Diagnosis of Whipple's Disease

Whipple's disease is both rare and enigmatic. It usually presents in middle-aged men, but in the 80 or so years since it was first described, fewer than 10 cases per year have been reported in the world's literature. 1 The most common clinical presentation is a malabsorption syndrome, alth...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 332; no. 6; pp. 390 - 392
Main Author Dobbins, William O
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 09.02.1995
Subjects
Acids
Actinomycetaceae - genetics
Actinomycetaceae - isolation & purification
Actinomycetaceae - ultrastructure
Antibiotics
Bacteria
Biopsy
Chronic Disease
Disease
Editorials
Eyes & eyesight
Female
Fever
Gastroenterology
Humans
Male
Medical diagnosis
Microscopy
Middle Aged
Nervous system
Patients
Polymerase Chain Reaction
RNA, Bacterial - isolation & purification
Sarcoidosis
Stains & staining
Uveitis - microbiology
Whipple Disease - diagnosis
Whipple Disease - microbiology
Whipple's disease
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Summary:Whipple's disease is both rare and enigmatic. It usually presents in middle-aged men, but in the 80 or so years since it was first described, fewer than 10 cases per year have been reported in the world's literature. 1 The most common clinical presentation is a malabsorption syndrome, although patients may have severe arthralgias for years before diarrhea develops. Cardiac and central nervous system involvement is also common. Patients may present with fever of undetermined cause, a sarcoidosis-like illness, or a wasting syndrome. Because the illness is insidious in its onset, has a varied clinical presentation, and is rare, it is . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199502093320611