Impact and Intricacies of Bone Marrow Microenvironment in B-cell Lymphomas: From Biology to Therapy

Lymphoma, a group of widely prevalent hematological malignancies of lymphocyte origin, has become the focus of significant clinical research due to their high propensity for refractory/relapsed (R/R) disease, leading to poor prognostic outcomes. The complex molecular circuitry in lymphomas, especial...

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Published inInternational journal of molecular sciences Vol. 21; no. 3; p. 904
Main Authors Sircar, Anuvrat, Chowdhury, Sayan Mullick, Hart, Amber, Bell, William Connor, Singh, Satishkumar, Sehgal, Lalit, Epperla, Narendranath
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.01.2020
MDPI
Subjects
B-cell lymphoma
Biology
Bone marrow
bone marrow microenvironment
Chemotherapy
diffuse large b-cell lymphoma
drug resistance
follicular lymphoma
Hematology
Lymphocytes
Lymphocytes B
Lymphoma
Mantle cell lymphoma
Medical prognosis
Phenotypes
relapse
Review
Transplants & implants
Tumor cells
Tumor microenvironment
Tumors
mantle cell lymphoma
diffuse large B-cell lymphoma
drug resistance
follicular lymphoma
relapse
bone marrow microenvironment
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Summary:Lymphoma, a group of widely prevalent hematological malignancies of lymphocyte origin, has become the focus of significant clinical research due to their high propensity for refractory/relapsed (R/R) disease, leading to poor prognostic outcomes. The complex molecular circuitry in lymphomas, especially in the aggressive phenotypes, has made it difficult to find a therapeutic option that can salvage R/R disease. Furthermore, the association of lymphomas with the Bone Marrow (BM) microenvironment has been found to portend worse outcomes in terms of heightened chances of relapse and acquired resistance to chemotherapy. This review assesses the current therapy options in three distinct types of lymphomas: diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. It also explores the role of the BM tumor microenvironment as a secure 'niche' for lymphoma cells to grow, proliferate and survive. It further evaluates potential mechanisms through which the tumor cells can establish molecular connections with the BM cells to provide pro-tumor benefits, and discusses putative therapeutic strategies for disrupting the BM-lymphoma cell communication.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21030904