Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

• Published in: Applied biochemistry and biotechnology Vol. 172; no. 3; pp. 1254 - 1264
• Main Authors: Liu, Harris, Kim, Yoojeong, Mello, Kerrianne, Lovaasen, John, Shah, Apoorva, Rice, Norman, Yim, Jacqueline H., Pappas, Daphne, Klibanov, Alexander M.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2014; Springer; Springer Nature B.V
• Subjects: Aerosols; Aerosols - chemical synthesis; Aerosols - chemistry; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Antimicrobial agents; Antiviral drugs; Biochemistry; Biological and medical sciences; Biotechnology; Chemical synthesis; Chemistry; Chemistry and Materials Science; E coli; Escherichia coli; Escherichia coli - drug effects; Fundamental and applied biological sciences. Psychology; General aspects; Glass - chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Immobilization techniques; Influenza virus; Methods. Procedures. Technologies; Pharmacology; Plasma; Polyamines - chemical synthesis; Polyamines - chemistry; Polyethyleneimine - chemistry; Staphylococcus aureus - drug effects; Surface Properties - drug effects; Antiviral; Antibacterial; Immobilization by aerosol-assisted plasma deposition; alkylated polyethylenimine; Microbicidal coatings; Immobilization; Coatings; Antimicrobial agent; N-alkylated polyethylenimine; Polycation; Aerosols; Antibacterial agent; Deposition; Polyethylene imine
• ISSN: 0273-2289; 1559-0291
• DOI: 10.1007/s12010-013-0593-4

The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N , N -hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli , and virucidal against human influenza virus.