A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy

• Published in: Case reports in oncological medicine Vol. 2021; pp. 9982171 - 8
• Main Authors: Sipe, Bradley H., Običan, Sarah G., Henderson-Jackson, Evita, Riddle, Nicole D., Makanji, Rikesh, Gonzalez, Ricardo J., Brohl, Andrew S.
• Format: Journal Article
• Language: English
• Published: United States Hindawi 19.07.2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Abdomen; Biopsy; Cancer; Case Report; Case reports; Chemotherapy; Coronary vessels; Gestational age; Health aspects; Ifosfamide; Infants (Newborn); Laparoscopy; Magnetic resonance imaging; Neonatology; Obstetrics; Oncology; Pathology; Pregnancy; Pregnant women; Radiation; Sarcoma; Surgery; Florida
• ISSN: 2090-6706; 2090-6714
• DOI: 10.1155/2021/9982171

We report a case of a 25-year-old pregnant woman diagnosed with a large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment with doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. Following the first prepartum chemotherapy cycle, a decreased amniotic fluid index was noted, representing a potential complication of chemotherapy. Induction of labor was performed at 33 weeks gestation with excellent outcome in the newborn. This case highlights the complex medical decision-making process in the setting of cancer diagnosed during pregnancy, balancing oncologic and obstetric concerns, and to our knowledge is only the second reported case of synovial sarcoma treated with neoadjuvant cytotoxic chemotherapy in the antepartum period.