Outcomes of single brain metastasis treated with gamma knife stereotaxic radiosurgery(GKSR). Our experience on 103 cases

• Published in: IBRO neuroscience reports Vol. 14; pp. 138 - 145
• Main Authors: Bankole, Nourou Dine Adeniran, Melhaoui, Adyl, Arkha, Yasser, Semmar, Afaf, Bouyakhlef, Khalid, Jiddane, Mohamed, El Khamlichi, Abdeslam
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2023; Elsevier
• Subjects: Brain metastasis; Cancer; Gamma knife; Research Paper; Stereotaxic Radiosurgery; Stereotaxic Radiosurgery; GKSR; RPA; SRS; WBRT; HRa; Brain metastasis; HR; BM; Gamma knife; Cancer; HR, Hazard Ratio; SRS, stereotactic radiosurgery; HRa, Hazard Ratio adjust; WBRT, whole brain radiotherapy; RPA, recursive partitioning analysis; BM, Brain metastasis; GKSR, Gamma Knife stereotactic radiosurgery
• ISSN: 2667-2421; 2667-2421
• DOI: 10.1016/j.ibneur.2023.01.007

Brain metastases (BM) occur in the natural course of malignant tumors in 18–40% of cases. Their management has changed considerably over the past decade thanks to the advent of Gamma knife Stereotactic Radiosurgery (GKSR). We report our experience on Single Brain metastasis treated with (GKSR). Patients treated by Gamma Knife stereotaxic radiosurgery (GKSR) in our institution between 2009 and 2021 for Single BM were recorded retrospectively. A total of 103 patients (n = 52; 50.5% females) were included, with a mean age of 56.33 ± 11.33. Breast (n = 39, 37.9%) and lung (n = 36, 35%) were the common original location for the primary tumors. GKSR alone without prior surgery, radiotherapy, or chemotherapy was achieved in 81.5% (n = 84). Thirteen patients (15.1%) progressed in BM volume while finding the appearance of de novo BM in 5 (5.8%) patients. The median percentage of tumor control after radiosurgery treatment was 70% (IQR: 65–78) and only 26.2% (n = 27) of patients had > 80% tumor control and stability over the median follow-up time of 5 (95% CI, 4–6) months. We found only two cases of radionecrosis (1.9%). The median survival time was 5.21 (IQR, 3–8) months. Retreatment, recursive partitioning analysis (RPA) class, and tumor stability influenced the overall survival of BM respectively (Hazard Ratio adjust (HRa)= 5.610,p = 0.045; HRa= 6.133,p = 0.031; HRa= 22.463, p = 0.036). Stereotaxic Radiosurgery provides good results in terms of Overall survival with fewer neurocognitive disorders.RPA class and tumor control (stability) influenced the overall survival of single BM. •Gamma Knife Stereotactic radiosurgery(GKSR) achieved good outcomes in terms of OS with fewer neurocognitive disorders.•Retreatment, RPA class, and tumor stability after GKSR influenced the OS of BM.•Breast and lung remained the common original location for the primary tumors.