The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control

The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-depen...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 21; no. 3; p. 709
Main Authors Manzano-López, Javier, Monje-Casas, Fernando
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.01.2020
MDPI
Subjects
Cell adhesion & migration
Cell cycle
Cyclin-dependent kinases
Kinases
Localization
Phosphatase
Phosphorylation
Proteins
Review
Tumorigenesis
Yeast
genome stability
autophagy
cytokinesis
nucleolus
Cdc14
mitotic exit
phosphatase
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Summary:The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21030709