p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer

• Published in: International journal of molecular sciences Vol. 18; no. 6; p. 1284
• Main Authors: Kobayashi, Kazuhiro, Tomita, Hiroyuki, Shimizu, Masahito, Tanaka, Takuji, Suzui, Natsuko, Miyazaki, Tatsuhiko, Hara, Akira
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.06.2017; MDPI
• Subjects: Animals; Biomarkers; Carcinogenesis; Carcinogens; Classification; Colitis, Ulcerative - complications; Colitis, Ulcerative - genetics; Colitis, Ulcerative - pathology; Colon; Colon - pathology; Colonic Neoplasms - diagnosis; Colonic Neoplasms - etiology; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; Crypts; Dysplasia; Endoscopy; Gene Expression Regulation, Neoplastic; Genes; Humans; Immunohistochemistry; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Malignancy; Mutation; Neutrophils; Ovaries; p53 Protein; Patients; Proteins; Remission (Medicine); Review; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - genetics; Tumors; Ulcerative colitis; dysplasia; colitic cancer; ulcerative colitis; p53
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms18061284

Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation-dysplasia sequence, which is a major problem affecting the prognosis of patients with UC. It is therefore very important to detect malignancy from UC at an early stage. As precancerous lesions arising in UC, there are pathological adenomatous changes, basal cell changes, in situ anaplasia, clear cell changes, and pan-cellular change. It is considered that the mutation of the p53 gene plays a crucial role, and the protein expression of p53 in dysplastic crypts may serve as a good biomarker in the early stages of UC-associated colon carcinogenesis. Immunohistochemistry for p53 is a very valuable diagnostic tool in UC-associated colon cancers. However, protein expression of p53 is not always universal, and additional methods may be required to assess p53 status in UC-associated colon cancers.