Cytokine Receptors-Regulators of Antimycobacterial Immune Response

• Published in: International journal of molecular sciences Vol. 23; no. 3; p. 1112
• Main Authors: Druszczyńska, Magdalena, Godkowicz, Magdalena, Kulesza, Jakub, Wawrocki, Sebastian, Fol, Marek
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.01.2022; MDPI
• Subjects: Adaptive Immunity; Animals; Antigens; Binding sites; Cell activation; Cell differentiation; Chemokines; cytokine; Cytokine receptors; Cytokines; Cytokines - metabolism; Granulocytes; Granulomas; Humans; Immune response; Immune system; Immunity, Innate; Immunoglobulins; Immunosurveillance; Infections; Kinases; Lymphatic system; Lymphocytes; Mutation; mycobacteria; Mycobacterium Infections - genetics; Mycobacterium Infections - immunology; Neutrophils; Pathogens; Proteins; Receptors, Cytokine - genetics; Receptors, Cytokine - metabolism; Review; Signal Transduction; Tuberculosis; Tumor necrosis factor-TNF; cytokine; cytokine receptors; immune response; mycobacteria
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23031112

Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid killing and immune surveillance. This paper provides an overview of cytokine receptors important for the innate and adaptive immune responses against mycobacteria and discusses the implications of receptor gene defects for the course of mycobacterial infection.