Screening and identification of molecular targets for cancer therapy

• Published in: Cancer letters Vol. 387; pp. 3 - 9
• Main Authors: Abdelmoez, Alshaimaa, Coraça-Huber, Débora C, Thurner, Gudrun C, Debbage, Paul, Lukas, Peter, Skvortsov, Sergej, Skvortsova, Ira
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.02.2017; Elsevier Limited
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Apoptosis; Cancer; Cancer stem cells; Cell cycle; Cell growth; Cellular membranes; Disease; Hematology, Oncology and Palliative Medicine; High-Throughput Screening Assays; Humans; Immunoglobulins; Medical research; Metastasis; Molecular Targeted Therapy; Neoplasm Proteins - antagonists & inhibitors; Neoplasms - drug therapy; Physiology; Proteomics; Radiation therapy; Researchers; Signal transduction; Signaling pathways; Target; Tumors; cellular membranes, proteomics; cancer; signaling pathways; cancer stem cells; target; Signaling pathways; Target; Cellular membranes; Cancer stem cells; Proteomics; Cancer
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.03.002

Highlights • Novel targeted therapeutics can help to combat tumor insensitivity to currently existing therapeutic approaches resulting in recurrence development; • Carcinoma cell membranes represent a large potential source of druggable therapeutic targets; • Proteomics is a promising tool for developing potential therapeutic targets; • Proteome-based evaluation of membrane fractions helps to detect potential therapeutic targets