Association of vitamin D deficiency with post-exercise hypotension and arterial stiffness following prolonged endurance exercise in healthy young men

• Published in: Journal of the International Society of Sports Nutrition Vol. 21; no. 1; p. 2410426
• Main Authors: Chen, Liang-You, Wang, Chun-Wei, Chen, Lu-An, He, Cheng-Shiun
• Format: Journal Article
• Language: English
• Published: United States Routledge 01.12.2024; Taylor & Francis Group
• Subjects: 25(OH)D; Adult; aerobic exercise; Blood Pressure; Exercise - physiology; Exercise Test; Humans; Male; Oxygen Consumption; Physical Endurance - physiology; Post-exercise hypotension; Post-Exercise Hypotension - etiology; Post-Exercise Hypotension - physiopathology; Pulse Wave Analysis; vascular elasticity; vascular function; Vascular Stiffness - physiology; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - complications; Young Adult; aerobic exercise; vascular elasticity; 25(OH)D; vascular function; Post-exercise hypotension
• ISSN: 1550-2783; 1550-2783
• DOI: 10.1080/15502783.2024.2410426

Vitamin D is associated with vascular function; however, the impact of different vitamin D levels on vascular elasticity following prolonged exercise remains uncertain. The primary objective of this study was to investigate the association of vitamin D levels with changes in peripheral pulse wave velocity (pPWV) and the magnitude of acute post-exercise hypotension (PEH) following prolonged endurance exercise in healthy young men. All the participants were divided into two groups: the 25-hydroxyvitamin D (25(OH)D) sufficiency group (25(OH)D ≧50 nmol/L) and the deficiency group (25(OH)D < 50 nmol/L). A cardiopulmonary exercise test for maximal oxygen uptake ( O ) was performed on the graded cycling. The prolonged exercise was set at 60% O for 120 min of continuous riding on a stationary bicycle. The pPWV and blood pressure were measured at baseline and 0, 15, 30, 45, 60 min after prolonged endurance exercise. Post hoc analysis revealed that the vitamin D sufficient group had a greater magnitude of PEH than the deficiency group at post-45 min. Multiple linear regression analyses showed a significant correlation between 25(OH)D and both pPWV (  = 0.036) and PEH (  = 0.007), after adjusting for O , weight, height, and physical activity. In addition, the 25(OH)D deficiency group also had higher pPWV at post-15 min (5.41 ± 0.93 vs 4.84 ± 0.75 m/s), post-30 min (5.30 ± 0.77 vs 4.87 ± 0.50 m/s), post-45 min (5.56 ± 0.93 vs 5.05 ± 0.68 m/s) than the sufficiency group. There was a positive correlation between 25(OH)D levels and systolic PEH following prolonged endurance exercise. Individuals with sufficient 25(OH)D status may have better vascular elasticity and more efficient blood pressure regulation during exercise.