Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification

Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological charac...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 18; no. 10; p. 2195
Main Author Inamura, Kentaro
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.10.2017
MDPI
Subjects
Adult
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Classification
Epidemiology
Gene Expression Regulation, Neoplastic
genetic alteration
Genetic Predisposition to Disease
histology
Humans
immunohistochemistry
kidney
Kidney cancer
Kidney Neoplasms - classification
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidney stones
molecular pathology
Prognosis
Renal cell carcinoma
Review
Tumors
World Health Organization
kidney
renal cell carcinoma
immunohistochemistry
histology
molecular pathology
genetic alteration
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Summary:Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18102195