Platelet-Rich Plasma Applications for Achilles Tendon Repair: A Bridge between Biology and Surgery

• Published in: International journal of molecular sciences Vol. 22; no. 2; p. 824
• Main Authors: Padilla, Sabino, Sánchez, Mikel, Vaquerizo, Victor, Malanga, Gerard A, Fiz, Nicolás, Azofra, Juan, Rogers, Christopher J, Samitier, Gonzalo, Sampson, Steven, Seijas, Roberto, Elorriaga, Ricardo, Taunton, Jack, Boehm, Frank, Prado, Roberto, Cugat, Ramón, Anitua, Eduardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.01.2021; MDPI
• Subjects: Achilles; Achilles tendon; Achilles Tendon - injuries; Achilles Tendon - surgery; Biology; Biomechanics; Blood platelets; Cell Cycle; Cell Movement; Cell Proliferation; Collagen - chemistry; Cytokines; ErbB Receptors - metabolism; Erythrocytes; Fibroblasts; Gene expression; Growth factors; Humans; Integrin beta1 - metabolism; Keratinocytes - cytology; Keratinocytes - metabolism; Leukocytes; Ligands; NF-kappa B - metabolism; Plasma; platelet-rich plasma; Platelet-Rich Plasma - metabolism; PRGF; Receptor, IGF Type 1 - metabolism; Review; Rupture - surgery; Signal Transduction; Standardization; tendon; Tendon Injuries - surgery; Tendons; Tissue engineering; Ultrasonic imaging; Wound Healing; tendon; PRGF; platelet-rich plasma; Achilles
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22020824

Achilles tendon ruptures are very common tendon ruptures and their incidence is increasing in modern society, resulting in work incapacity and months off sport, which generate a need for accelerated and successful therapeutic repair strategy. Platelet-rich plasma (PRP) is emerging as adjuvant human blood-derived constructs to assist Achilles tendon rupture treatment. However, myriad PRP preparation methods in conjunction with poor standardization in the modalities of their applications impinge on the consistent effectiveness of clinical and structural outcomes regarding their therapeutic efficacy. The purpose of this review is to provide some light on the application of PRP for Achilles tendon ruptures. PRP has many characteristics that make it an attractive treatment. Elements such as the inclusion of leukocytes and erythrocytes within PRP, the absence of activation and activation ex vivo or in vivo, the modality of application, and the adjustment of PRP pH can influence the biology of the applied product and result in misleading therapeutic conclusions. The weakest points in demonstrating their consistent effectiveness are primarily the result of myriad PRP preparation methods and the poor standardization of modalities for their application. Selecting the right biological scaffold and applying it correctly to restitutio ad integrum of ruptured Achilles tendons remains a daunting and complex task.