Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therap...

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Published inAnnals of medicine (Helsinki) Vol. 56; no. 1; p. 2346543
Main Authors Wu, Qinrui, Huang, Fengjuan
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.12.2024
Taylor & Francis Group
Subjects
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic nephropathy
Endocrinology
ferroptosis
Ferroptosis - drug effects
glomerular endothelial cell
Humans
Iron - metabolism
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Lipid Metabolism - drug effects
mesangial cell
podocyte
Reactive Oxygen Species - metabolism
Review
TEC
Diabetic nephropathy
TEC
ferroptosis
mesangial cell
glomerular endothelial cell
podocyte
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Abstract Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metabolism, lipid metabolism, and the accumulation of ROS. Recently, many studies testified to the significance of ferroptosis in kidney tissue under diabetic conditions and explored the drugs targeting ferroptosis in DN therapy. Our review summarized the most current studies between ferroptosis and DN, along with investigating the significant processes of ferroptosis in different kidney cells, providing a novel target treatment option for DN.
AbstractList Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metabolism, lipid metabolism, and the accumulation of ROS. Recently, many studies testified to the significance of ferroptosis in kidney tissue under diabetic conditions and explored the drugs targeting ferroptosis in DN therapy. Our review summarized the most current studies between ferroptosis and DN, along with investigating the significant processes of ferroptosis in different kidney cells, providing a novel target treatment option for DN.
AbstractDiabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metabolism, lipid metabolism, and the accumulation of ROS. Recently, many studies testified to the significance of ferroptosis in kidney tissue under diabetic conditions and explored the drugs targeting ferroptosis in DN therapy. Our review summarized the most current studies between ferroptosis and DN, along with investigating the significant processes of ferroptosis in different kidney cells, providing a novel target treatment option for DN.
Author Wu, Qinrui
Huang, Fengjuan
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Issue 1
Keywords Diabetic nephropathy
TEC
ferroptosis
mesangial cell
glomerular endothelial cell
podocyte
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
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Snippet Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However,...
AbstractDiabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern....
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SubjectTerms Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic nephropathy
Endocrinology
ferroptosis
Ferroptosis - drug effects
glomerular endothelial cell
Humans
Iron - metabolism
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Lipid Metabolism - drug effects
mesangial cell
podocyte
Reactive Oxygen Species - metabolism
Review
TEC
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Title Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy
URI https://www.ncbi.nlm.nih.gov/pubmed/38657163
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Volume 56
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