Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy

• Published in: Annals of medicine (Helsinki) Vol. 56; no. 1; p. 2346543
• Main Authors: Wu, Qinrui, Huang, Fengjuan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2024; Taylor & Francis Group
• Subjects: Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Diabetic nephropathy; Endocrinology; ferroptosis; Ferroptosis - drug effects; glomerular endothelial cell; Humans; Iron - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Lipid Metabolism - drug effects; mesangial cell; podocyte; Reactive Oxygen Species - metabolism; Review; TEC; Diabetic nephropathy; TEC; ferroptosis; mesangial cell; glomerular endothelial cell; podocyte
• ISSN: 0785-3890; 1365-2060
• DOI: 10.1080/07853890.2024.2346543

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metabolism, lipid metabolism, and the accumulation of ROS. Recently, many studies testified to the significance of ferroptosis in kidney tissue under diabetic conditions and explored the drugs targeting ferroptosis in DN therapy. Our review summarized the most current studies between ferroptosis and DN, along with investigating the significant processes of ferroptosis in different kidney cells, providing a novel target treatment option for DN.