Environmental Surveillance Complements Case-Based Surveillance of Acute Flaccid Paralysis in Polio Endgame Strategy 2019-2023

• Published in: Applied and environmental microbiology Vol. 86; no. 15
• Main Authors: Chen, Peng, Liu, Yao, Wang, Haiyan, Liu, Guifang, Lin, Xiaojuan, Zhang, Weiyan, Ji, Feng, Xu, Qing, Tao, Zexin, Xu, Aiqiang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 20.07.2020
• Subjects: Children; China; Enterovirus - isolation & purification; Enteroviruses; Environmental Monitoring; Eradication; Health risks; Health surveillance; Humans; Paralysis; Paralysis - diagnosis; Phylogeny; Poliomyelitis; Poliomyelitis - complications; Poliomyelitis - diagnosis; Poliomyelitis - prevention & control; Poliovirus - isolation & purification; Population Surveillance; Public and Environmental Health Microbiology; Sewage; Spotlight; Vaccine-associated paralytic poliomyelitis; Vaccines; China; acute flaccid paralysis surveillance; enterovirus; environmental surveillance; oral polio vaccine; poliomyelitis
• ISSN: 0099-2240; 1098-5336
• DOI: 10.1128/aem.00702-20

The Polio Endgame Strategy 2019-2023 has been developed. However, more effective and efficient surveillance activities should be conducted with the preparedness of emergence for vaccine-derived poliovirus (VDPV) or wild poliovirus (WPV). We reviewed the impact of the case-based acute flaccid paralysis (AFP) surveillance (1991 to 2018) and environmental surveillance (2011 to 2018) in polio eradication in Shandong province of China. Clinical characteristics of AFP cases and enterovirus (EV) investigation of research samples were assessed. During the period, 10,224 AFP cases were investigated, and 352 sewage samples were collected. The nonpolio AFP rate sustained at over 2.0/100,000 since 1997. Of 10,224 cases, males and young children experienced a higher risk of severe diseases, and 68.5% suffered lower limb paralysis. We collected 1,707 EVs from AFP cases, including 763 polioviruses and 944 nonpolio enteroviruses (NPEVs). No WPV was isolated since 1992. The AFP surveillance showed high sensitivity in detecting 143 vaccine-associated paralytic poliomyelitis (VAPP) cases and 6 VDPVs. For environmental surveillance, 217 (61.6%) samples were positive for poliovirus, and altogether, 838 polioviruses and 2,988 NPEVs were isolated. No WPV was isolated in environmental surveillance, although one VDPV2 was identified. Phylogenetic analysis revealed environmental surveillance had the capacity to detect a large scope of NPEVs. The case-based AFP surveillance will be indispensable for detecting VAPP cases and VDPV circulation in countries using oral polio vaccine. Environmental surveillance is advantageous in identifying EV circulation and responding to ongoing circulating VDPV outbreaks and should be expanded to complement the AFP surveillance. Interrupting wild poliovirus transmission and stopping circulating vaccine-derived poliovirus (cVDPV) outbreaks have been proposed as two global goals by the World Health Organization in the Global Polio Eradication Initiative (GPEI). This analysis, based on the 28-year acute flaccid paralysis (AFP) surveillance and 8-year environmental surveillance, provides continued high-quality surveillance performance in achieving the GPEI and detecting the circulation of enterovirus. Given the ongoing cVDPV outbreaks in the world, we present the surveillance capacity of environmental surveillance in capturing enterovirus circulation. The final poliovirus (especially VDPV) elimination has become increasingly complex, and the case-based AFP surveillance alone will lead to difficulties in early detecting dynamics of poliovirus transmission and monitoring the extent of environmental circulation. This study goes beyond previous work to provide a detailed comprehensive evaluation of the enterovirus surveillance and can be used to formulate a set of implementation plan and performance indicators for environmental surveillance.