Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype

• Published in: International journal of molecular sciences Vol. 19; no. 12; p. 4002
• Main Authors: Pluta, Ryszard, Ułamek-Kozioł, Marzena, Czuczwar, Stanisław J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.12.2018; MDPI
• Subjects: Alzheimer Disease - drug therapy; Alzheimer's disease; Amyloid; Amyloidogenesis; Animal cognition; Animals; Antioxidants; Apoptosis; Atrophy; autophagy; Brain damage; Brain injury; brain ischemia; Brain Ischemia - drug therapy; Chemical compounds; Curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; Death; Dementia; Dementia disorders; Disintegration; Excitotoxicity; genes; Genotype & phenotype; Humans; Hyperhomocysteinemia; Inflammation; Ischemia; Life span; Mitochondria; mitophagy; Neurodegeneration; Neurogenesis; Neurons; Neuropathology; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Nootropic Agents - pharmacology; Nootropic Agents - therapeutic use; Oxidants; Oxidizing agents; Peptides; Permeability; Pharmacology; Phenotype; Phenotypes; Proteins; Review; Stroke; Structure-function relationships; Tau protein; Traumatic brain injury; mitophagy; amyloid; autophagy; brain ischemia; Alzheimer’s disease; genes; neurodegeneration; apoptosis; tau protein; curcumin
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms19124002

In recent years, ongoing interest in ischemic brain injury research has provided data showing that ischemic episodes are involved in the development of Alzheimer's disease-like neuropathology. Brain ischemia is the second naturally occurring neuropathology, such as Alzheimer's disease, which causes the death of neurons in the CA1 region of the hippocampus. In addition, brain ischemia was considered the most effective predictor of the development of full-blown dementia of Alzheimer's disease phenotype with a debilitating effect on the patient. Recent knowledge on the activation of Alzheimer's disease-related genes and proteins-e.g., amyloid protein precursor and tau protein-as well as brain ischemia and Alzheimer's disease neuropathology indicate that similar processes contribute to neuronal death and disintegration of brain tissue in both disorders. Although brain ischemia is one of the main causes of death in the world, there is no effective therapy to improve the structural and functional outcomes of this disorder. In this review, we consider the promising role of the protective action of curcumin after ischemic brain injury. Studies of the pharmacological properties of curcumin after brain ischemia have shown that curcumin has several therapeutic properties that include anti-excitotoxic, anti-oxidant, anti-apoptotic, anti-hyperhomocysteinemia and anti-inflammatory effects, mitochondrial protection, as well as increasing neuronal lifespan and promoting neurogenesis. In addition, curcumin also exerts anti-amyloidogenic effects and affects the brain's tau protein. These results suggest that curcumin may be able to serve as a potential preventive and therapeutic agent in neurodegenerative brain disorders.