Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 1; pp. 3 - 22
• Main Authors: Maze, Ian, Noh, Kyung-Min, Allis, C David
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2013
• Subjects: Animals; Biology; Central nervous system; Central Nervous System - physiology; Chromatin - physiology; Chromatin remodeling; Circuits; Drug development; Enzymes; Epigenetics; Epigenomics - methods; Epigenomics - trends; Gene expression; Histones; Histones - physiology; Humans; Integration; Intellectual disabilities; Intracellular signalling; Memory; Mutation; Nervous system; Nervous System Diseases - genetics; Nervous System Diseases - metabolism; Neurological diseases; Neurological disorders; Neuronal Plasticity - physiology; Neurons; Neuropsychopharmacology Reviews; Plasticity (behavioral); Proteins; Psychiatry; Reviews; Transcription; New York; United States > US

Postmitotic neurons are subject to a vast array of environmental influences that require the nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic states associated with synaptic function, circuit formation, and behavioral memory. Over the last decade, much...