The Recovery Index: A Novel Approach to Measuring Recovery and Predicting Remission in Major Depressive Disorder

Abstract Background Clinicians view “recovery” as being the reduction in a quantity of symptoms over time, whereas patients view it as the restoration of premorbid functioning level and as their quality of life (QOL). The main purpose of this study is to incorporate patient-reported measures of func...

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Bibliographic Details
Published inJournal of affective disorders Vol. 208; pp. 369 - 374
Main Authors IsHak, Waguih William, Bonifay, Wes, Collison, Katherine, Reid, Mark, Youssef, Haidy, Parisi, Thomas, Cohen, Robert, Cai, Li
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.01.2017
Subjects
Activities of Daily Living
Depression
Depressive Disorder, Major - classification
Depressive Disorder, Major - rehabilitation
Functioning
Humans
Major depressive disorder
Prognosis
Psychiatric Status Rating Scales
Psychiatry
Quality of Life
Recovery
Remission
Remission Induction
STARD
functioning
major depressive disorder
remission
Depression
recovery
quality of life
STAR⁎D
Remission
STARD
Recovery
Major depressive disorder
Functioning
Quality of life
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Summary:Abstract Background Clinicians view “recovery” as being the reduction in a quantity of symptoms over time, whereas patients view it as the restoration of premorbid functioning level and as their quality of life (QOL). The main purpose of this study is to incorporate patient-reported measures of functioning and QOL into the assessment of patient outcomes in MDD and to use this data to predict recovery. Method Using the STAR⁎D study of patients diagnosed with MDD, this present analysis grades patients’ MDD severity, functioning level, and QOL at exit from each level of the study, as well as at follow-up. Using Item Response Theory, we combined patient data from functioning and QOL measures (WSAS, Q-LES-Q) in order to form a single latent dimension named the Recovery Index. Results Recovery Index – a latent measure assessing impact of illness on functioning and QOL – is able to predict remission of MDD in patients who participated in the STAR⁎D study. Conclusions By incorporating functioning and quality of life, the Recovery index creates a new dimension towards measuring restoration of health to move beyond basic symptom measurement.
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ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2016.08.081