The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review...

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Published inInternational journal of molecular sciences Vol. 23; no. 3; p. 1255
Main Authors Hsueh, Yi-Jen, Chen, Yen-Ning, Tsao, Yu-Ting, Cheng, Chao-Min, Wu, Wei-Chi, Chen, Hung-Chi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.01.2022
MDPI
Subjects
Aging
Angiogenesis
Antioxidants
Antioxidants - metabolism
Apoptosis
Autophagy
Biomarkers
Cataract - pathology
Cornea
DNA damage
Enzymes
Eye - metabolism
Eye diseases
Eye Diseases - pathology
Eye Diseases - therapy
Free radicals
Gene expression
Glaucoma - pathology
Humans
Inflammation
Lens, Crystalline - metabolism
Lipid peroxidation
Lipids
Macular Degeneration - pathology
Mitochondrial DNA
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Pathogenesis
Proteins
Reactive Oxygen Species
Review
Signal transduction
Uric acid
Vascular endothelial growth factor
antioxidant biomarkers
antioxidant therapy
oxidative stress
ocular diseases
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Abstract Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.
AbstractList Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.
Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.
Author Chen, Yen-Ning
Cheng, Chao-Min
Tsao, Yu-Ting
Hsueh, Yi-Jen
Chen, Hung-Chi
Wu, Wei-Chi
AuthorAffiliation 2 Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan
3 Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan
4 Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30012, Taiwan; chaomin@mx.nthu.edu.tw
1 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan; t6612@seed.net.tw (Y.-J.H.); annie850924@gmail.com (Y.-N.C.); sherry450047@gmail.com (Y.-T.T.); weichi666@gmail.com (W.-C.W.)
AuthorAffiliation_xml – name: 4 Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30012, Taiwan; chaomin@mx.nthu.edu.tw
– name: 1 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan; t6612@seed.net.tw (Y.-J.H.); annie850924@gmail.com (Y.-N.C.); sherry450047@gmail.com (Y.-T.T.); weichi666@gmail.com (W.-C.W.)
– name: 2 Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan
– name: 3 Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan
Author_xml – sequence: 1
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  orcidid: 0000-0003-3380-7188
  surname: Hsueh
  fullname: Hsueh, Yi-Jen
– sequence: 2
  givenname: Yen-Ning
  orcidid: 0000-0001-7860-3862
  surname: Chen
  fullname: Chen, Yen-Ning
– sequence: 3
  givenname: Yu-Ting
  orcidid: 0000-0002-6231-6014
  surname: Tsao
  fullname: Tsao, Yu-Ting
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  givenname: Chao-Min
  orcidid: 0000-0002-8644-1960
  surname: Cheng
  fullname: Cheng, Chao-Min
– sequence: 5
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  surname: Wu
  fullname: Wu, Wei-Chi
– sequence: 6
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  orcidid: 0000-0002-1117-7878
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  fullname: Chen, Hung-Chi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35163178$$D View this record in MEDLINE/PubMed
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Snippet Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and...
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StartPage 1255
SubjectTerms Aging
Angiogenesis
Antioxidants
Antioxidants - metabolism
Apoptosis
Autophagy
Biomarkers
Cataract - pathology
Cornea
DNA damage
Enzymes
Eye - metabolism
Eye diseases
Eye Diseases - pathology
Eye Diseases - therapy
Free radicals
Gene expression
Glaucoma - pathology
Humans
Inflammation
Lens, Crystalline - metabolism
Lipid peroxidation
Lipids
Macular Degeneration - pathology
Mitochondrial DNA
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Pathogenesis
Proteins
Reactive Oxygen Species
Review
Signal transduction
Uric acid
Vascular endothelial growth factor
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Title The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases
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