Insights into the Effects of Mesenchymal Stem Cell-Derived Secretome in Parkinson's Disease

Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like those reported after MSCs transplantation. MSC-derived secretome may avoid various side effects of MSC-based therapy, comprising undesirable differentiation of engrafted MSCs and potential activation of the allogenei...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 21; no. 15; p. 5241
Main Authors d'Angelo, Michele, Cimini, Annamaria, Castelli, Vanessa
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.07.2020
MDPI
Subjects
Animals
Antioxidants
Apoptosis
Biomarkers
Blood-brain barrier
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Cell Differentiation
Deoxyribonucleic acid
Disease
Disease Models, Animal
DNA
Dopamine
Exosomes
Exosomes - metabolism
Exosomes - pathology
Exosomes - transplantation
extravesicles
Growth factors
Immune response
Inflammation
Membranes
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Mesenchymal Stem Cells - pathology
Metabolism
MicroRNAs
Mutation
Neurotrophic factors
Oxidation
Oxidative stress
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson Disease - therapy
Parkinson's disease
Pathogenesis
Physiology
Polymorphism
Proteins
Review
Secretome
Signal transduction
Signs and symptoms
Stem cells
Transplantation
Transplants & implants
conditioned medium
stem cells
extravesicles
exosomes
mesenchymal stem cells
secretome
Parkinson’s disease
Online AccessGet full text

Cover

Abstract Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like those reported after MSCs transplantation. MSC-derived secretome may avoid various side effects of MSC-based therapy, comprising undesirable differentiation of engrafted MSCs and potential activation of the allogeneic immune response. MSC-derived secretome comprises soluble factors and encapsulated extravesicles (EVs). MSC-derived EVs comprise microvesicles, apoptotic bodies, and exosomes. In this review, we focus on the recent insights into the effects of MSC-derived secretome in Parkinson's disease (PD). In particular, MSC-derived secretome and exosomal components counteracted neuroinflammation and enhanced antioxidant capacity and neurotrophic factors expression. In light of the insights reported in this review, MSC-derived secretome or their released exosomes may be used as a potential therapeutic approach or as adjuvant therapy to counteract the disease progression and improve PD symptoms. Also, MSC-derived secretome may be used as a vehicle in cell transplantation approaches to enhance the viability and survival of engrafted cells. Furthermore, since exosomes can cross the blood-brain barrier, they may be used as biomarkers of neural dysfunction. Further studies are necessary to fully characterize the bioactive molecules present in the secretome and to create a new, effective, cell-free therapeutic approach towards a robust clinical outcome for PD patients.
AbstractList Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like those reported after MSCs transplantation. MSC-derived secretome may avoid various side effects of MSC-based therapy, comprising undesirable differentiation of engrafted MSCs and potential activation of the allogeneic immune response. MSC-derived secretome comprises soluble factors and encapsulated extravesicles (EVs). MSC-derived EVs comprise microvesicles, apoptotic bodies, and exosomes. In this review, we focus on the recent insights into the effects of MSC-derived secretome in Parkinson’s disease (PD). In particular, MSC-derived secretome and exosomal components counteracted neuroinflammation and enhanced antioxidant capacity and neurotrophic factors expression. In light of the insights reported in this review, MSC-derived secretome or their released exosomes may be used as a potential therapeutic approach or as adjuvant therapy to counteract the disease progression and improve PD symptoms. Also, MSC-derived secretome may be used as a vehicle in cell transplantation approaches to enhance the viability and survival of engrafted cells. Furthermore, since exosomes can cross the blood–brain barrier, they may be used as biomarkers of neural dysfunction. Further studies are necessary to fully characterize the bioactive molecules present in the secretome and to create a new, effective, cell-free therapeutic approach towards a robust clinical outcome for PD patients.
Author Castelli, Vanessa
d'Angelo, Michele
Cimini, Annamaria
AuthorAffiliation Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy; michele.dangelo@univaq.it (M.A.); annamaria.cimini@univaq.it (A.C.)
AuthorAffiliation_xml – name: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy; michele.dangelo@univaq.it (M.A.); annamaria.cimini@univaq.it (A.C.)
Author_xml – sequence: 1
  givenname: Michele
  orcidid: 0000-0002-3693-840X
  surname: d'Angelo
  fullname: d'Angelo, Michele
  organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy
– sequence: 2
  givenname: Annamaria
  surname: Cimini
  fullname: Cimini, Annamaria
  organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy
– sequence: 3
  givenname: Vanessa
  orcidid: 0000-0002-7005-3218
  surname: Castelli
  fullname: Castelli, Vanessa
  organization: Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32718092$$D View this record in MEDLINE/PubMed
BookMark eNpVkd1rFDEUxYO02A9981kCPvji2HxNMvMiyLbqQotC9cmHkMnc7GadSdokW-h_b-rWsoVAwr0nv3sP5wQdhBgAoTeUfOS8J2d-M2dGadsyQV-gYyoYawiR6mDvfYROct4Qwjhr-5foiDNFO9KzY_R7GbJfrUvGPpSIyxrwhXNgayE6fAUZgl3fz2bC1wVmvIBpas4h-TsY8TXYBCXOUP_iHyb98SHH8D7jc5_BZHiFDp2ZMrx-vE_Rry8XPxffmsvvX5eLz5eNFaorjSKDHamlox1ZLztZTbXCCUEM4wM3MDjroKWjYq2Uveg7oqQDonoqa49zfoqWO-4YzUbfJD-bdK-j8fpfIaaVNql4O4F2pKuHDqIzUkjHjZIWCB9Za5ixilXWpx3rZjvMMFoIJZnpGfR5J_i1XsU7rQRnVMoKePcISPF2C7noTdymUP1rJlhPqotWVdWHncqmmHMC9zSBEv0Qq96Ptcrf7m_1JP6fI_8Lr5Of2g
CitedBy_id crossref_primary_10_4103_bc_bc_8_21
crossref_primary_10_1186_s13036_023_00361_9
crossref_primary_10_3390_biom13081250
crossref_primary_10_3390_ijms22031433
crossref_primary_10_3390_ijms231710138
crossref_primary_10_3389_fcell_2020_602647
crossref_primary_10_15283_ijsc22137
crossref_primary_10_3390_brainsci11050552
crossref_primary_10_1007_s12015_021_10222_x
crossref_primary_10_32604_biocell_2022_018306
crossref_primary_10_3390_ijms21218060
crossref_primary_10_15283_ijsc22014
crossref_primary_10_1007_s11010_023_04700_8
crossref_primary_10_1016_j_biopha_2021_112026
crossref_primary_10_4103_1673_5374_335143
crossref_primary_10_3389_fbioe_2023_1139359
crossref_primary_10_1016_j_neuroscience_2022_11_017
crossref_primary_10_1088_1741_2552_ad33b2
crossref_primary_10_3390_biomedicines9060667
crossref_primary_10_1007_s12015_023_10618_x
crossref_primary_10_18632_aging_203088
crossref_primary_10_3389_fnins_2024_1210447
crossref_primary_10_3390_cells10081992
crossref_primary_10_3390_ijms23137306
crossref_primary_10_1016_j_neulet_2021_136414
crossref_primary_10_3389_fnmol_2022_1061076
crossref_primary_10_3390_cells11213476
crossref_primary_10_1016_j_neulet_2021_136094
crossref_primary_10_14336_AD_2020_1221
crossref_primary_10_3389_fneur_2022_950715
crossref_primary_10_1093_jnen_nlac037
crossref_primary_10_1186_s13287_022_03050_4
crossref_primary_10_3389_fcell_2021_770510
crossref_primary_10_1111_cns_14677
crossref_primary_10_3390_ijms22115665
crossref_primary_10_3390_ijms23137047
crossref_primary_10_4103_1673_5374_390956
crossref_primary_10_1002_sctm_20_0268
crossref_primary_10_1016_j_reth_2022_08_003
crossref_primary_10_1016_j_sciaf_2024_e02274
crossref_primary_10_3390_antiox10071088
crossref_primary_10_3390_ijms25042444
crossref_primary_10_4103_1673_5374_350193
Cites_doi 10.3171/2014.11.JNS14770
10.3389/fncel.2018.00317
10.1002/mdc3.12692
10.3389/fnmol.2016.00128
10.1080/14712598.2018.1546840
10.3390/cells8050467
10.3390/cells8020118
10.1111/jnc.13036
10.3390/ijms20071656
10.1161/STROKEAHA.116.015204
10.1021/nn404945r
10.1126/science.276.5321.2045
10.1186/s13287-019-1484-6
10.3390/ijms15034142
10.1007/s00018-020-03454-6
10.3402/jev.v4.26238
10.3390/ijms18122698
10.1186/s13578-020-00427-x
10.1002/mds.27116
10.3390/biology8020038
10.3390/ijms20236055
10.1126/science.aam9080
10.1007/978-3-030-31206-0_4
10.3390/ijms19102877
10.3390/cells8080886
10.15586/codonpublications.parkinsonsdisease.2018.ch1
10.1186/1471-2202-11-52
10.5772/61186
10.3390/ijms21113807
10.1186/s13287-019-1398-3
10.3390/jcm7100357
10.1016/j.brainres.2009.11.041
10.1007/s12035-017-0681-5
10.3389/fbioe.2019.00294
10.3389/fneur.2019.00122
10.1634/stemcells.2005-0330
10.3389/fnmol.2019.00132
10.1002/mds.27119
10.1155/2018/9415367
10.3389/fimmu.2019.00446
10.2147/IJN.S159404
10.1002/stem.1129
10.3402/jev.v4.26316
10.1186/s13578-019-0282-2
10.1080/17425247.2019.1645116
10.3390/ijms21031170
10.1016/j.brainres.2007.09.086
10.15283/ijsc19108
10.1038/nrd.2018.136
10.1523/JNEUROSCI.5427-08.2009
10.1007/s00441-014-1866-0
10.1177/1759091418777438
10.1186/s12964-015-0124-8
10.1038/mt.2015.44
10.1002/jcp.29872
10.1038/s41582-019-0305-y
10.3727/096368915X689938
10.3389/fbioe.2019.00292
10.1002/sctm.18-0226
10.1016/j.febslet.2014.12.014
10.18632/aging.102927
10.3389/fcell.2020.00086
10.5966/sctm.2016-0111
10.1038/s41598-018-19211-6
10.1038/s41585-019-0169-3
10.1002/jcb.29722
10.1186/s13287-016-0316-1
10.1007/s12013-014-0354-1
10.1177/0963689717723636
10.3389/fnmol.2019.00080
10.1155/2014/965849
10.3390/ijms18091852
10.1038/aps.2017.162
10.1194/jlr.E086173
10.3389/fimmu.2018.02837
10.1155/2016/5736059
10.1016/j.jcyt.2014.07.013
10.7150/ijms.41515
10.1038/s41419-020-2473-5
10.1038/nature22815
10.1186/s40364-019-0159-x
10.1021/acsnano.7b04495
10.2174/1389202914666131210213042
10.1002/pmic.200600284
10.1155/2019/2105607
10.3389/fnmol.2017.00352
10.1016/j.bbi.2013.03.007
ContentType Journal Article
Copyright 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2020 by the authors. 2020
Copyright_xml – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2020 by the authors. 2020
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
5PM
DOA
DOI 10.3390/ijms21155241
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
AUTh Library subscriptions: ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest research library
Research Library (Corporate)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
DatabaseTitleList

CrossRef
MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID oai_doaj_org_article_f08f081b48a646f3a76ce03d25a2ac72
10_3390_ijms21155241
32718092
Genre Journal Article
Review
GroupedDBID ---
29J
2WC
3V.
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
ABDBF
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CGR
CS3
CUY
CVF
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
ECM
EIF
EJD
ESTFP
ESX
F5P
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
ITC
KB.
KQ8
LK8
M1P
M2O
M48
M7P
MODMG
M~E
NPM
O5R
O5S
OK1
P2P
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNS
RPM
TR2
TUS
UKHRP
~8M
AAYXX
CITATION
7XB
8FK
K9.
MBDVC
PQEST
PQUKI
PRINS
Q9U
5PM
AFPKN
ID FETCH-LOGICAL-c478t-70bcd1c1dcd2968639054f440a23b3aebfcfe51d725669498076fe07916ebf333
IEDL.DBID RPM
ISSN 1422-0067
1661-6596
IngestDate Tue Oct 22 15:13:22 EDT 2024
Tue Sep 17 21:22:36 EDT 2024
Sat Nov 09 07:16:46 EST 2024
Mon Oct 14 10:46:34 EDT 2024
Wed Oct 16 00:44:18 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 15
Keywords conditioned medium
stem cells
extravesicles
exosomes
mesenchymal stem cells
secretome
Parkinson’s disease
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-70bcd1c1dcd2968639054f440a23b3aebfcfe51d725669498076fe07916ebf333
ORCID 0000-0002-3693-840X
0000-0002-7005-3218
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432166/
PMID 32718092
PQID 2429072557
PQPubID 2032341
ParticipantIDs doaj_primary_oai_doaj_org_article_f08f081b48a646f3a76ce03d25a2ac72
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7432166
proquest_journals_2429072557
crossref_primary_10_3390_ijms21155241
pubmed_primary_32718092
PublicationCentury 2000
PublicationDate 20200723
PublicationDateYYYYMMDD 2020-07-23
PublicationDate_xml – month: 7
  year: 2020
  text: 20200723
  day: 23
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2020
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Dias (ref_36) 2013; 3
ref_90
Yalvac (ref_60) 2013; 32
ref_58
Recasens (ref_83) 2016; 9
ref_13
Hu (ref_41) 2006; 6
Minjarez (ref_79) 2018; 12
Adamo (ref_12) 2019; 10
Yu (ref_45) 2020; 8
Betzer (ref_53) 2017; 11
Yin (ref_50) 2019; 7
Dorszewska (ref_46) 2014; 15
Cha (ref_14) 2018; 8
ref_18
Sulzer (ref_33) 2017; 546
Yao (ref_71) 2016; 25
Tuazon (ref_19) 2019; 16
ref_15
Zhang (ref_84) 2014; 2014
Vaccari (ref_77) 2015; 136
Parga (ref_61) 2017; 55
Wood (ref_82) 2020; 16
Pawitan (ref_16) 2014; 2014
Tatullo (ref_96) 2020; 17
Marques (ref_70) 2018; 18
ref_67
ref_66
Ramos (ref_8) 2016; 14
Weiss (ref_57) 2006; 24
ref_65
Imai (ref_56) 2015; 4
ref_29
Orgaz (ref_34) 2017; 32
ref_27
Tunaitis (ref_80) 2015; 17
Busato (ref_51) 2017; 75
Lopez (ref_52) 2017; 38
Nakhaeifard (ref_62) 2018; 20
Zhang (ref_76) 2015; 122
Chen (ref_81) 2020; 11
Li (ref_85) 2020; 2020
Ferreira (ref_5) 2018; 9
McKelvey (ref_74) 2015; 4
Charvin (ref_47) 2018; 17
Wiklander (ref_48) 2015; 4
Chung (ref_32) 2009; 29
Luarte (ref_40) 2016; 2016
Zhang (ref_43) 2019; 9
Polymeropoulos (ref_28) 1997; 276
Kabaria (ref_86) 2014; 589
ref_30
Zeng (ref_38) 2018; 10
Ottolini (ref_24) 2014; 357
ref_39
Phelps (ref_6) 2018; 2018
ref_37
Castelli (ref_25) 2020; 12
Khanmohammadi (ref_21) 2018; 20
Record (ref_44) 2018; 59
Baek (ref_55) 2019; 8
Xin (ref_91) 2012; 30
Almeria (ref_10) 2019; 7
Xin (ref_75) 2013; 33
Samanta (ref_7) 2017; 39
Rani (ref_17) 2015; 23
Cai (ref_93) 2020; 10
Dabrowska (ref_9) 2018; 13
Wu (ref_95) 2018; 5
Cookson (ref_31) 2017; 32
Yu (ref_72) 2014; 15
Baharlooi (ref_73) 2020; 13
Park (ref_92) 2019; 10
Oh (ref_64) 2016; 6
Arshad (ref_88) 2017; 10
ref_89
Lai (ref_54) 2014; 8
ref_87
ref_42
ref_1
Choi (ref_49) 2016; 7
ref_2
Han (ref_78) 2014; 71
Shintani (ref_69) 2007; 1186
Castelli (ref_23) 2019; 12
Burbulla (ref_35) 2017; 357
Cova (ref_59) 2010; 1311
Sun (ref_22) 2019; 16
Caggiu (ref_26) 2019; 10
Qiu (ref_11) 2019; 10
ref_4
Mercado (ref_63) 2017; 2
Li (ref_68) 2019; 12
Xin (ref_94) 2017; 48
Chang (ref_3) 2018; 27
Tuazon (ref_20) 2019; 1201
References_xml – volume: 122
  start-page: 856
  year: 2015
  ident: ref_76
  article-title: Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
  publication-title: J. Neurosurg.
  doi: 10.3171/2014.11.JNS14770
  contributor:
    fullname: Zhang
– volume: 2020
  start-page: 5146253
  year: 2020
  ident: ref_85
  article-title: The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson’s Disease: A Resting-State fMRI Study
  publication-title: Park. Dis.
  contributor:
    fullname: Li
– volume: 12
  start-page: 317
  year: 2018
  ident: ref_79
  article-title: Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2018.00317
  contributor:
    fullname: Minjarez
– volume: 5
  start-page: 614
  year: 2018
  ident: ref_95
  article-title: Circadian Rest-Activity Rhythms Predict Cognitive Function in Early Parkinson’s Disease Independently of Sleep
  publication-title: Mov. Disord. Clin. Pract.
  doi: 10.1002/mdc3.12692
  contributor:
    fullname: Wu
– volume: 9
  start-page: 128
  year: 2016
  ident: ref_83
  article-title: Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic Review
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2016.00128
  contributor:
    fullname: Recasens
– volume: 18
  start-page: 1235
  year: 2018
  ident: ref_70
  article-title: Cell secretome based approaches in Parkinson’s disease regenerative medicine
  publication-title: Expert Opin. Boil. Ther.
  doi: 10.1080/14712598.2018.1546840
  contributor:
    fullname: Marques
– ident: ref_4
  doi: 10.3390/cells8050467
– ident: ref_90
  doi: 10.3390/cells8020118
– volume: 75
  start-page: 3
  year: 2017
  ident: ref_51
  article-title: Labeling and Magnetic Resonance Imaging of Exosomes Isolated from Adipose Stem Cells
  publication-title: Curr. Protoc. Cell Boil.
  contributor:
    fullname: Busato
– volume: 136
  start-page: 39
  year: 2015
  ident: ref_77
  article-title: Exosome-mediated inflammasome signaling after central nervous system injury
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.13036
  contributor:
    fullname: Vaccari
– ident: ref_15
  doi: 10.3390/ijms20071656
– volume: 48
  start-page: 747
  year: 2017
  ident: ref_94
  article-title: MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.116.015204
  contributor:
    fullname: Xin
– volume: 3
  start-page: 461
  year: 2013
  ident: ref_36
  article-title: The Role of Oxidative Stress in Parkinson’s Disease
  publication-title: J. Park. Dis.
  contributor:
    fullname: Dias
– volume: 8
  start-page: 483
  year: 2014
  ident: ref_54
  article-title: Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter
  publication-title: ACS Nano
  doi: 10.1021/nn404945r
  contributor:
    fullname: Lai
– volume: 276
  start-page: 2045
  year: 1997
  ident: ref_28
  article-title: Mutation in the -Synuclein Gene Identified in Families with Parkinson’s Disease
  publication-title: Science
  doi: 10.1126/science.276.5321.2045
  contributor:
    fullname: Polymeropoulos
– volume: 10
  start-page: 1
  year: 2019
  ident: ref_11
  article-title: Functional proteins of mesenchymal stem cell-derived extracellular vesicles
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-019-1484-6
  contributor:
    fullname: Qiu
– volume: 15
  start-page: 4142
  year: 2014
  ident: ref_72
  article-title: Exosomes Derived from Mesenchymal Stem Cells
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms15034142
  contributor:
    fullname: Yu
– ident: ref_2
  doi: 10.1007/s00018-020-03454-6
– volume: 4
  start-page: 26238
  year: 2015
  ident: ref_56
  article-title: Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice
  publication-title: J. Extracell. Vesicles
  doi: 10.3402/jev.v4.26238
  contributor:
    fullname: Imai
– ident: ref_87
  doi: 10.3390/ijms18122698
– volume: 2
  start-page: 2
  year: 2017
  ident: ref_63
  article-title: BDNF in the Aged Brain: Translational Implications for Parkinson’s Disease
  publication-title: Austin Neurol. Neurosci.
  contributor:
    fullname: Mercado
– volume: 10
  start-page: 1
  year: 2020
  ident: ref_93
  article-title: Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential
  publication-title: Cell Biosci.
  doi: 10.1186/s13578-020-00427-x
  contributor:
    fullname: Cai
– volume: 32
  start-page: 1327
  year: 2017
  ident: ref_31
  article-title: Alpha-synuclein triggers T-cell response. Is Parkinson’s disease an autoimmune disorder?
  publication-title: Mov. Disord.
  doi: 10.1002/mds.27116
  contributor:
    fullname: Cookson
– ident: ref_30
  doi: 10.3390/biology8020038
– ident: ref_89
  doi: 10.3390/ijms20236055
– volume: 357
  start-page: 1255
  year: 2017
  ident: ref_35
  article-title: Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
  publication-title: Science
  doi: 10.1126/science.aam9080
  contributor:
    fullname: Burbulla
– volume: 1201
  start-page: 79
  year: 2019
  ident: ref_20
  article-title: Neural Stem Cells
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-030-31206-0_4
  contributor:
    fullname: Tuazon
– ident: ref_42
  doi: 10.3390/ijms19102877
– volume: 2014
  start-page: 938348
  year: 2014
  ident: ref_84
  article-title: miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70
  publication-title: Sci. World J.
  contributor:
    fullname: Zhang
– ident: ref_1
  doi: 10.3390/cells8080886
– ident: ref_27
  doi: 10.15586/codonpublications.parkinsonsdisease.2018.ch1
– ident: ref_58
  doi: 10.1186/1471-2202-11-52
– volume: 4
  start-page: 7
  year: 2015
  ident: ref_74
  article-title: Exosomes: Mechanisms of Uptake
  publication-title: J. Circ. Biomark.
  doi: 10.5772/61186
  contributor:
    fullname: McKelvey
– volume: 33
  start-page: 1711
  year: 2013
  ident: ref_75
  article-title: Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Xin
– ident: ref_67
  doi: 10.3390/ijms21113807
– volume: 10
  start-page: 288
  year: 2019
  ident: ref_92
  article-title: Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-019-1398-3
  contributor:
    fullname: Park
– ident: ref_13
  doi: 10.3390/jcm7100357
– volume: 1311
  start-page: 12
  year: 2010
  ident: ref_59
  article-title: Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson’s disease
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2009.11.041
  contributor:
    fullname: Cova
– volume: 55
  start-page: 4763
  year: 2017
  ident: ref_61
  article-title: Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-017-0681-5
  contributor:
    fullname: Parga
– ident: ref_65
  doi: 10.3389/fbioe.2019.00294
– volume: 10
  start-page: 122
  year: 2019
  ident: ref_26
  article-title: Inflammation, Infectious Triggers, and Parkinson’s Disease
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2019.00122
  contributor:
    fullname: Caggiu
– volume: 24
  start-page: 781
  year: 2006
  ident: ref_57
  article-title: Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson’s Disease
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0330
  contributor:
    fullname: Weiss
– volume: 12
  start-page: 132
  year: 2019
  ident: ref_23
  article-title: Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2019.00132
  contributor:
    fullname: Castelli
– volume: 32
  start-page: 1409
  year: 2017
  ident: ref_34
  article-title: N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson’s disease
  publication-title: Mov. Disord.
  doi: 10.1002/mds.27119
  contributor:
    fullname: Orgaz
– volume: 2018
  start-page: 9415367
  year: 2018
  ident: ref_6
  article-title: Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics
  publication-title: Stem Cells Int.
  doi: 10.1155/2018/9415367
  contributor:
    fullname: Phelps
– volume: 10
  start-page: 446
  year: 2019
  ident: ref_12
  article-title: Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00446
  contributor:
    fullname: Adamo
– volume: 13
  start-page: 1653
  year: 2018
  ident: ref_9
  article-title: Imaging of extracellular vesicles derived from human bone marrow mesenchymal stem cells using fluorescent and magnetic labels
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S159404
  contributor:
    fullname: Dabrowska
– volume: 30
  start-page: 1556
  year: 2012
  ident: ref_91
  article-title: Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
  publication-title: Stem Cells
  doi: 10.1002/stem.1129
  contributor:
    fullname: Xin
– volume: 4
  start-page: 26316
  year: 2015
  ident: ref_48
  article-title: Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
  publication-title: J. Extracell. Vesicles
  doi: 10.3402/jev.v4.26316
  contributor:
    fullname: Wiklander
– volume: 9
  start-page: 1
  year: 2019
  ident: ref_43
  article-title: Exosomes: biogenesis, biologic function and clinical potential
  publication-title: Cell Biosci.
  doi: 10.1186/s13578-019-0282-2
  contributor:
    fullname: Zhang
– volume: 16
  start-page: 823
  year: 2019
  ident: ref_19
  article-title: Drug-like delivery methods of stem cells as biologics for stroke
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1080/17425247.2019.1645116
  contributor:
    fullname: Tuazon
– ident: ref_39
  doi: 10.3390/ijms21031170
– volume: 1186
  start-page: 48
  year: 2007
  ident: ref_69
  article-title: Protection of dopamine neurons by bone marrow stromal cells
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2007.09.086
  contributor:
    fullname: Shintani
– volume: 13
  start-page: 13
  year: 2020
  ident: ref_73
  article-title: Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases
  publication-title: Int. J. Stem Cells
  doi: 10.15283/ijsc19108
  contributor:
    fullname: Baharlooi
– volume: 17
  start-page: 804
  year: 2018
  ident: ref_47
  article-title: Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2018.136
  contributor:
    fullname: Charvin
– volume: 29
  start-page: 3365
  year: 2009
  ident: ref_32
  article-title: Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.5427-08.2009
  contributor:
    fullname: Chung
– volume: 357
  start-page: 439
  year: 2014
  ident: ref_24
  article-title: Calcium signaling in Parkinson’s disease
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-014-1866-0
  contributor:
    fullname: Ottolini
– volume: 10
  start-page: 1
  year: 2018
  ident: ref_38
  article-title: Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment
  publication-title: ASN Neuro
  doi: 10.1177/1759091418777438
  contributor:
    fullname: Zeng
– volume: 14
  start-page: 2
  year: 2016
  ident: ref_8
  article-title: MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry
  publication-title: Cell Commun. Signal.
  doi: 10.1186/s12964-015-0124-8
  contributor:
    fullname: Ramos
– volume: 23
  start-page: 812
  year: 2015
  ident: ref_17
  article-title: Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2015.44
  contributor:
    fullname: Rani
– ident: ref_66
  doi: 10.1002/jcp.29872
– volume: 16
  start-page: 65
  year: 2020
  ident: ref_82
  article-title: MicroRNAs - diagnostic markers in Parkinson disease?
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-019-0305-y
  contributor:
    fullname: Wood
– volume: 25
  start-page: 1101
  year: 2016
  ident: ref_71
  article-title: Combined MSC-Secreted Factors and Neural Stem Cell Transplantation Promote Functional Recovery of PD Rats
  publication-title: Cell Transplant.
  doi: 10.3727/096368915X689938
  contributor:
    fullname: Yao
– volume: 20
  start-page: 10
  year: 2018
  ident: ref_21
  article-title: Effect of Transplantation of Bone Marrow Stromal Cell- Conditioned Medium on Ovarian Function, Morphology and Cell Death in Cyclophosphamide-Treated Rats
  publication-title: Cell J.
  contributor:
    fullname: Khanmohammadi
– volume: 7
  start-page: 292
  year: 2019
  ident: ref_10
  article-title: Hypoxia Conditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Increased Vascular Tube Formation in vitro
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2019.00292
  contributor:
    fullname: Almeria
– volume: 8
  start-page: 880
  year: 2019
  ident: ref_55
  article-title: Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform
  publication-title: Stem Cells Transl. Med.
  doi: 10.1002/sctm.18-0226
  contributor:
    fullname: Baek
– volume: 589
  start-page: 319
  year: 2014
  ident: ref_86
  article-title: Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson’s disease
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2014.12.014
  contributor:
    fullname: Kabaria
– volume: 12
  start-page: 4641
  year: 2020
  ident: ref_25
  article-title: Effects of the probiotic formulation SLAB51 in in vitro and in vivo Parkinson’s disease models
  publication-title: Aging
  doi: 10.18632/aging.102927
  contributor:
    fullname: Castelli
– volume: 8
  start-page: 86
  year: 2020
  ident: ref_45
  article-title: Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis
  publication-title: Front. Cell Dev. Boil.
  doi: 10.3389/fcell.2020.00086
  contributor:
    fullname: Yu
– volume: 6
  start-page: 949
  year: 2016
  ident: ref_64
  article-title: The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2016-0111
  contributor:
    fullname: Oh
– volume: 8
  start-page: 1171
  year: 2018
  ident: ref_14
  article-title: Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-19211-6
  contributor:
    fullname: Cha
– volume: 16
  start-page: 363
  year: 2019
  ident: ref_22
  article-title: Harnessing the mesenchymal stem cell secretome for regenerative urology
  publication-title: Nat. Rev. Urol.
  doi: 10.1038/s41585-019-0169-3
  contributor:
    fullname: Sun
– ident: ref_29
  doi: 10.1002/jcb.29722
– volume: 7
  start-page: 55
  year: 2016
  ident: ref_49
  article-title: Illuminating the physiology of extracellular vesicles
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-016-0316-1
  contributor:
    fullname: Choi
– volume: 71
  start-page: 1341
  year: 2014
  ident: ref_78
  article-title: Anti-inflammatory Mechanism of Bone Marrow Mesenchymal Stem Cell Transplantation in Rat Model of Spinal Cord Injury
  publication-title: Cell Biophys.
  doi: 10.1007/s12013-014-0354-1
  contributor:
    fullname: Han
– volume: 27
  start-page: 349
  year: 2018
  ident: ref_3
  article-title: Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
  publication-title: Cell Transplant.
  doi: 10.1177/0963689717723636
  contributor:
    fullname: Chang
– volume: 12
  start-page: 80
  year: 2019
  ident: ref_68
  article-title: Conditioned Medium of Human Menstrual Blood-Derived Endometrial Stem Cells Protects Against MPP+-Induced Cytotoxicity in vitro
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2019.00080
  contributor:
    fullname: Li
– volume: 2014
  start-page: 965849
  year: 2014
  ident: ref_16
  article-title: Prospect of Stem Cell Conditioned Medium in Regenerative Medicine
  publication-title: BioMed Res. Int.
  doi: 10.1155/2014/965849
  contributor:
    fullname: Pawitan
– ident: ref_18
  doi: 10.3390/ijms18091852
– volume: 39
  start-page: 501
  year: 2017
  ident: ref_7
  article-title: Exosomes: new molecular targets of diseases
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2017.162
  contributor:
    fullname: Samanta
– volume: 59
  start-page: 1316
  year: 2018
  ident: ref_44
  article-title: Extracellular vesicles: Lipids as key components of their biogenesis and functions
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.E086173
  contributor:
    fullname: Record
– volume: 9
  start-page: 2837
  year: 2018
  ident: ref_5
  article-title: Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02837
  contributor:
    fullname: Ferreira
– volume: 2016
  start-page: 5736059
  year: 2016
  ident: ref_40
  article-title: Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/5736059
  contributor:
    fullname: Luarte
– volume: 17
  start-page: 932
  year: 2015
  ident: ref_80
  article-title: Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis
  publication-title: Cytotherapy
  doi: 10.1016/j.jcyt.2014.07.013
  contributor:
    fullname: Tunaitis
– volume: 17
  start-page: 657
  year: 2020
  ident: ref_96
  article-title: Exosomes from Human Periapical Cyst-MSCs: Theranostic Application in Parkinson’s Disease
  publication-title: Int. J. Med Sci.
  doi: 10.7150/ijms.41515
  contributor:
    fullname: Tatullo
– volume: 11
  start-page: 288
  year: 2020
  ident: ref_81
  article-title: Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-2473-5
  contributor:
    fullname: Chen
– volume: 20
  start-page: 348
  year: 2018
  ident: ref_62
  article-title: Conditioned Medium Protects Dopaminergic Neurons in Parkinsonian Rats
  publication-title: Cell J.
  contributor:
    fullname: Nakhaeifard
– volume: 546
  start-page: 656
  year: 2017
  ident: ref_33
  article-title: T cells from patients with Parkinson’s disease recognize α-synuclein peptides
  publication-title: Nature
  doi: 10.1038/nature22815
  contributor:
    fullname: Sulzer
– volume: 38
  start-page: 767
  year: 2017
  ident: ref_52
  article-title: Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Lopez
– volume: 7
  start-page: 8
  year: 2019
  ident: ref_50
  article-title: Exosomes from mesenchymal stem/stromal cells: A new therapeutic paradigm
  publication-title: Biomark. Res.
  doi: 10.1186/s40364-019-0159-x
  contributor:
    fullname: Yin
– volume: 11
  start-page: 10883
  year: 2017
  ident: ref_53
  article-title: In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b04495
  contributor:
    fullname: Betzer
– volume: 15
  start-page: 11
  year: 2014
  ident: ref_46
  article-title: Molecular Effects of L-dopa Therapy in Parkinson’s Disease
  publication-title: Curr. Genom.
  doi: 10.2174/1389202914666131210213042
  contributor:
    fullname: Dorszewska
– volume: 6
  start-page: 6326
  year: 2006
  ident: ref_41
  article-title: Human body fluid proteome analysis
  publication-title: Proteomics
  doi: 10.1002/pmic.200600284
  contributor:
    fullname: Hu
– ident: ref_37
  doi: 10.1155/2019/2105607
– volume: 10
  start-page: 352
  year: 2017
  ident: ref_88
  article-title: MicroRNAs and Target Genes As Biomarkers for the Diagnosis of Early Onset of Parkinson Disease
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2017.00352
  contributor:
    fullname: Arshad
– volume: 32
  start-page: 122
  year: 2013
  ident: ref_60
  article-title: Characterization of the secretome of human tooth germ stem cells (hTGSCs) reveals neuro-protection by fine-tuning micro-environment
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2013.03.007
  contributor:
    fullname: Yalvac
SSID ssj0023259
Score 2.5232263
SecondaryResourceType review_article
Snippet Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like those reported after MSCs transplantation. MSC-derived secretome may avoid...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 5241
SubjectTerms Animals
Antioxidants
Apoptosis
Biomarkers
Blood-brain barrier
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Cell Differentiation
Deoxyribonucleic acid
Disease
Disease Models, Animal
DNA
Dopamine
Exosomes
Exosomes - metabolism
Exosomes - pathology
Exosomes - transplantation
extravesicles
Growth factors
Immune response
Inflammation
Membranes
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Mesenchymal Stem Cells - pathology
Metabolism
MicroRNAs
Mutation
Neurotrophic factors
Oxidation
Oxidative stress
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson Disease - therapy
Parkinson's disease
Pathogenesis
Physiology
Polymorphism
Proteins
Review
Secretome
Signal transduction
Signs and symptoms
Stem cells
Transplantation
Transplants & implants
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7Et-uLHPQYbJM0aY8-UWG9rAtepCRpgituV2wVvPk3_Hv-EidNd9kVwYvQU9u0YSbtfB-Z-QahA4jKhVBJQYxQlHCrHNGOx0TT1Cmfd5FqX43cvRGXfX59l9xNtfryOWFBHjgY7shFKRyx5qkSXDimpPAtrgqaKKqMDH_fKBuTqZZqMdq0SYsh-hCRZCKkvDMg-EeDx2EFrCdJKI9nglGj2f8b0PyZLzkVgC6W0VKLHPFxmPEKmrPlKloIvSTf19D9VVl5ol3hQVmPMOA6HJSJKzxyuOuLjMzD-xCe0KvtEJ_apydyBsvvzRa457FjPRpaGIt9HXRTEvb18Vnhs7CBs476F-e3p5ek7Z1ADJdpTWSkTRGbuDAFzUQKOASwmeM8UpRppqx2xtkkLiRAHpHxLI2kcDaSgBbhGmNsA82Xo9JuISyYyWycGJv6LUsqtBHUKQ1Aw9jMGtVBh2Mj5s9BIiMHauGNnU8bu4NOvIUn93hh6-YEuDtv3Z3_5e4O2h37J2-_tioHmAEcH8iR7KDN4KrJWxiVXqIMBsoZJ85MY_ZKOXhodLYBXFFYQdv_Me8dtEg9U48koWwXzdcvr3YP4Eyt95uV-w2sJvQJ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4s1CQT7A0Wr8iO2cELQsBalcSqVeUOQn3aqblCYg9cbf4O_xS5hJsksXIaSc4jiJZsae77PHM4S8AK8ctSsjC9oJppLLzGfFmRc2O4y7sB5PIx981PtH6sNxeTwtuHVTWOVqThwm6tgGXCPfAVcCPA4AsHl1_pVh1SjcXZ1KaFwnN7gwBsmXnb9bEy4phmJpHHwQ02Wlx8B3CTR_Z3G67ID7lKVQfMMlDZn7_wU3_46avOKG5nfI7Qk_0tejwu-Sa6m5R26OFSUv75PP75sO6XZHF03fUkB3dMxP3NE20wM8ahROLpfwhsM-LeluOjtje2CE31Okh4gg-3aZoC_F09DDwbBfP352dG_cxnlAjuZvP-3us6mCAgvK2J6ZwofIA48hikpbQCOA0LJShRPSS5d8DjmVPIJcta5UZQujcyoMYEZok1I-JFtN26THhGoZqsTLkCxuXArtgxbZeYAbIVUpuBl5uRJifT4myqiBYKCw66vCnpE3KOH1M5jeerjRXnypp9FS58LCxb2yTiudpTMa65pFUTrhghEzsr3STz2Nua7-YyEz8mhU1forUhhMVAYdzYYSN35js6VZnAzZtgFiCbCgJ___5FNySyATLwwTcpts9Rff0jOAK71_Ptjkb3Tv64Y
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB5VrVr1gspfCZTKBzgaEtuxkwNC0FK1SOVSVuqlimzHpot2E9iEqnvjNXg9noRxsll1S0-VcoozSTQzlr9P8wfwCk_lUuq0pFZqRoXTnhovEmpY5nXIu8hMqEY-_SKPR-LzeXq-BsO00YUCmzupXZgnNZpN3lz_nL_HDf8uME6k7G_H36cN8pg0ZaGCfYMJ5OghiU8s4wkIG9K8T3v_T2IbtjhToY0VWzmbuhb-d-HO2-mTN86jox14sACS5ENv-Yew5qpHsNmPlpw_houTqgm8uyHjqq0JwjzSNypuSO3Jaag5spfzKb7hrHVTcuAmE3qI3njlSnIWoGRbTx3KklAW3VWI_f39pyGHfTznCYyOPn09OKaLUQrUCpW1VMXGlolNSluyXGYISxCqeSFizbjh2hlvvUuTUiECkrnIs1hJ72KF4BHXOOdPYb2qK_cMiOQ2d0lqXRYimEwaK5nXBnGHdbmzOoLXgxKLH33HjAKZRtB7cVPvEXwMGl4-E_pcdzfq2bdisW0KH2d4JUZkWgrpuVYyDDgrWaqZtopFsDfYpxh8p0DUgZQfuZKKYLc31fIrg6kjUCtGXPmN1ZVqfNm13UasxRIpn99b8gVss8DWY0UZ34P1dvbLvURI05r9zlv_AUAL-Y8
  priority: 102
  providerName: Scholars Portal
Title Insights into the Effects of Mesenchymal Stem Cell-Derived Secretome in Parkinson's Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/32718092
https://www.proquest.com/docview/2429072557
https://pubmed.ncbi.nlm.nih.gov/PMC7432166
https://doaj.org/article/f08f081b48a646f3a76ce03d25a2ac72
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB61RaBeEP8ESuQDHNNNbMfOHum2S0HaqqJU2guKbMduF22SqglIvfEavB5Pwjg_VRdxQop8iOPEmplovs-eGQO8Ra9cCJUWkRGKRtwqF2nHk0jTzCkfd5Fpn428OBHH5_zTMl1uQTrmwnRB-0av9qt1uV-tLrvYyqvSTMY4scnpYoZejyZCTLZhGw10pOgDy2II6PsId4Z8frL6VjZIctIUXdUuPGBU-opVdMMNddX6_wUx_46UvON65o_g4YAZyft-bo9hy1ZP4H5_iuTNU_j6sWo8xW7IqmprgoiO9DWJG1I7svDpRebypsQ3nLW2JDO7XkeHaHg_bEHOPGps69LiWOIzoLtksN8_fzXksN-6eQbn86Mvs-NoODUhMlxmbSRjbYrEJIUp6FRkiEAQlTnOY0WZZspqZ5xNk0Ii2BFTPs1iKZyNJeJE7GOMPYedqq7sSyCCmalNUmMzv1lJhTaCOqURYhg7tUYF8G4UYn7VF8fIkVR4ued35R7AgZfw7TO-pHV3o76-yAfF5i7O8Eo0z5TgwjElhT_LrKCpospIGsDeqJ98-M-aHAEGsnukRTKAF72qbr8yqjoAuaHEjWls9qDBdRW2BwN79d8jX8Mu9cQ8lhFle7DTXn-3bxC9tDpEm11KbLP5hxDuHRydnH4Ou5WA0HuVFNsFz8LOpv8A2On4pg
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12068,12777,21400,24330,27936,27937,31731,33385,33756,43322,43612,43817,53804,53806,74073,74363,74630
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEYJLxZuFAj7A0WpiO3ZyqqBl2UK3l7ZSLyjys13UTUqTVuqNv8Hf45cwTrJLFyGknOI4tmbGnm_seQC8Ra3spM4ctVIzKrwO1ASRUsPyoKPfRW5iNPJ0X06OxOfj7Hg4cGsGt8rFntht1K628Yx8E1UJ2nEIgNXW-Xcaq0bF29WhhMZtuCM46uoYKT7-tDS4OOuKpaWog6jMCtk7vnM08zdn3-YN2j5ZxkS6opK6zP3_gpt_e03eUEPjB7A-4Efyvmf4Q7jlq0dwt68oef0Yvu5WTTS3GzKr2poguiN9fuKG1IFMY6iRPb2e4x8OWj8n2_7sjO6gEF55Rw4igmzruce-JEZDd4Fhv378bMhOf43zBI7GHw-3J3SooECtUHlLVWKsS23qrGOFzBGNIEILQiSaccO1N8EGn6UO6SplIYo8UTL4RCFmxDbO-VNYq-rKPwciuS18mlmfx4tLJo2VLGiDcMP6wls9gncLIpbnfaKMEg2MSOzyJrFH8CFSePlNTG_dvagvTsphtZQhyfFJjci1FDJwrWSsa-ZYppm2io1gY8GfclhzTflHQkbwrGfVchTOVExUhh3VChNXprHaUs1Ou2zbCLEYStCL_w_5Bu5NDqd75d7u_peXcJ9FqzxRlPENWGsvLv0rhC6ted3J52-Mke5o
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELagCNQL4r8LBXyAo7WJ7djJCUGXVQu0QiqV9oIi_9KtuknbBKTeeI2-Xp-EmSTbdhFCyimO42hm7Pm-eDxDyBvwyl6ZzDOnDGcymMhslCmzPI8G4y5yi6eRd_fU9oH8NMtmQ_xTM4RVLtfEbqH2tcN_5GNwJcDjAADrcRzCIr5Opu9OThlWkMKd1qGcxm1yRwNLQZvXs2vyJXhXOC0Ff8RUVqg-CF4A5R_PjxYN8KAs4zJdcU9dFv9_Qc-_IyhvuKTpA3J_wJL0fa_8h-RWqB6Ru311yfPH5PtO1SD1bui8amsKSI_2uYobWke6i8eO3OH5At6w34YF3QrHx2wCBvkreLqPaLKtFwH6UjwZ3R0Su_x90dBJv6XzhBxMP37b2mZDNQXmpM5bphPrfOpS7zwvVA7IBNBalDIxXFhhgo0uhiz1IGOlClnkiVYxJBrwI7QJIZ6StaquwgahSrgipJkLOW5icmWd4tFYgB4uFMGZEXm7FGJ50ifNKIFsoLDLm8IekQ8o4atnMNV1d6M--1EOM6eMSQ5XamVulFRRGK2wxpnnmeHGaT4im0v9lMP8a8praxmRZ72qrkYRXGPSMuioV5S48hmrLdX8sMu8DXCLgwU9__-Qr8k9MM3yy87e5xdknSNBTzTjYpOstWc_w0tAMa191ZnnH5u-8qA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insights+into+the+Effects+of+Mesenchymal+Stem+Cell-Derived+Secretome+in+Parkinson%E2%80%99s+Disease&rft.jtitle=International+journal+of+molecular+sciences&rft.au=d%E2%80%99Angelo%2C+Michele&rft.au=Cimini%2C+Annamaria&rft.au=Castelli%2C+Vanessa&rft.date=2020-07-23&rft.pub=MDPI&rft.eissn=1422-0067&rft.volume=21&rft.issue=15&rft_id=info:doi/10.3390%2Fijms21155241&rft_id=info%3Apmid%2F32718092&rft.externalDBID=PMC7432166
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon