Molecular and clinical implications of loop diuretic ototoxicity

Recent advances in molecular biology have been applied to inner ear research. Loop diuretic ototoxicity has been suggested, but not proven, to share a common mechanism with diuretic effects on renal tubules. The discovery of the molecular nature of the Na-K-2Cl cotransporter in the cochlea provided...

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Published inHearing research Vol. 107; no. 1-2; pp. 1 - 8
Main Authors Ikeda, Katsuhisa, Oshima, Takeshi, Hidaka, Hiroshi, Takasaka, Tomonori
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.1997
Subjects
Animals
Carrier Proteins - genetics
Carrier Proteins - metabolism
Chlorides - metabolism
Cloning
Cochlea - drug effects
Cochlea - metabolism
Diuretics - toxicity
Ear, Inner - drug effects
Ear, Inner - metabolism
Humans
Ion transport
Loop diuretics
Loop of Henle - drug effects
Na-K-Cl cotransporter
Ototoxicity
Potassium - metabolism
Sodium - metabolism
Sodium-Potassium-Chloride Symporters
Ion transport
Na-K-Cl cotransporter
Loop diuretics
Cloning
Ototoxicity
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Summary:Recent advances in molecular biology have been applied to inner ear research. Loop diuretic ototoxicity has been suggested, but not proven, to share a common mechanism with diuretic effects on renal tubules. The discovery of the molecular nature of the Na-K-2Cl cotransporter in the cochlea provided a better understanding of loop diuretic ototoxicity. In this review, we describe clinical reports of loop diuretic ototoxicity and other information obtained by physiological, biochemical and morphological investigations related to the mechanism sensitive to loop diuretics. Based on recent evidence for the molecular nature of the Na-K-2Cl cotransporter expressed in the mammalian cochlea, the underlying mechanisms of ototoxicity induced by loop diuretics are described.
ISSN:0378-5955
1878-5891
DOI:10.1016/S0378-5955(97)00009-9