p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?

Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein kinase (MAPK) is one of several signaling pathways that drive the metabolic adaptation of skeletal muscle to exercise. p38 MAPK also particip...

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Published inInternational journal of molecular sciences Vol. 21; no. 18; p. 6480
Main Authors Bengal, Eyal, Aviram, Sharon, Hayek, Tony
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.09.2020
MDPI
Subjects
Adaptation
Animals
Biological Transport
Carbohydrate Metabolism
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Energy
energy metabolism
Enzymes
Exercise
Gene expression
Glucose
Glucose - metabolism
Glucose Intolerance - metabolism
Glucose tolerance
Homeostasis
Humans
Insulin
Insulin - metabolism
Insulin resistance
Insulin Resistance - physiology
Intolerance
Kinases
Lipids
Liver
MAP kinase
Metabolic disorders
Metabolic syndrome
Metabolism
Mitochondria
Muscle contraction
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Obesity
Obesity - metabolism
Oxidation resistance
Oxidative metabolism
p38 MAPK
p38 Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - physiology
Phosphorylation
Physical fitness
Protein kinase
Proteins
Review
signal transduction
Signal Transduction - physiology
Skeletal muscle
Transcription factors
type 2 diabetes
exercise
type 2 diabetes
skeletal muscle
signal transduction
p38 MAPK
energy metabolism
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Abstract Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein kinase (MAPK) is one of several signaling pathways that drive the metabolic adaptation of skeletal muscle to exercise. p38 MAPK also participates in the development of pathological traits resulting from excessive caloric intake and obesity that cause metabolic syndrome and type 2 diabetes (T2D). Whereas p38 MAPK increases insulin-independent glucose uptake and oxidative metabolism in muscles during exercise, it contrastingly mediates insulin resistance and glucose intolerance during metabolic syndrome development. This article provides an overview of the apparent contradicting roles of p38 MAPK in the adaptation of skeletal muscles to exercise and to pathological conditions leading to glucose intolerance and T2D. Here, we focus on the involvement of p38 MAPK in glucose metabolism of skeletal muscle, and discuss the possibility of targeting this pathway to prevent the development of T2D.
AbstractList Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein kinase (MAPK) is one of several signaling pathways that drive the metabolic adaptation of skeletal muscle to exercise. p38 MAPK also participates in the development of pathological traits resulting from excessive caloric intake and obesity that cause metabolic syndrome and type 2 diabetes (T2D). Whereas p38 MAPK increases insulin-independent glucose uptake and oxidative metabolism in muscles during exercise, it contrastingly mediates insulin resistance and glucose intolerance during metabolic syndrome development. This article provides an overview of the apparent contradicting roles of p38 MAPK in the adaptation of skeletal muscles to exercise and to pathological conditions leading to glucose intolerance and T2D. Here, we focus on the involvement of p38 MAPK in glucose metabolism of skeletal muscle, and discuss the possibility of targeting this pathway to prevent the development of T2D.
Author Bengal, Eyal
Hayek, Tony
Aviram, Sharon
AuthorAffiliation 1 Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel; avirams@technion.ac.il
2 Department of Internal Medicine E, Rambam Medical Center, Haifa 31096, Israel; t_hayek@rambam.health.gov.il
AuthorAffiliation_xml – name: 2 Department of Internal Medicine E, Rambam Medical Center, Haifa 31096, Israel; t_hayek@rambam.health.gov.il
– name: 1 Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel; avirams@technion.ac.il
Author_xml – sequence: 1
  givenname: Eyal
  surname: Bengal
  fullname: Bengal, Eyal
  organization: Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel
– sequence: 2
  givenname: Sharon
  surname: Aviram
  fullname: Aviram, Sharon
  organization: Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Haifa 31096, Israel
– sequence: 3
  givenname: Tony
  surname: Hayek
  fullname: Hayek, Tony
  organization: Department of Internal Medicine E, Rambam Medical Center, Haifa 31096, Israel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32899870$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1210/jc.2008-0574
10.1016/j.jhep.2014.12.032
10.1152/physrev.00038.2012
10.1074/jbc.M506223200
10.1083/jcb.201006098
10.1152/ajpendo.00578.2007
10.14814/phy2.12876
10.1152/ajpregu.00563.2003
10.1016/j.cmet.2014.09.018
10.1002/mus.22289
10.1126/science.286.5443.1368
10.1093/ageing/afh201
10.1038/35093131
10.1093/emboj/20.22.6414
10.1073/pnas.260501497
10.1016/S1097-2765(01)00390-2
10.1530/JOE-15-0302
10.1128/MCB.19.1.21
10.1038/nm.2449
10.1113/jphysiol.2008.165639
10.1210/en.2004-1294
10.1126/science.7824938
10.1073/pnas.1312039110
10.1016/j.freeradbiomed.2009.08.014
10.2337/diabetes.49.11.1794
10.1042/bj20031559
10.1074/jbc.M503486200
10.2337/diabetes.53.5.1208
10.1172/JCI31785
10.1074/jbc.M602177200
10.1152/ajpcell.2001.280.2.C352
10.1073/pnas.171184698
10.1038/embor.2010.160
10.1038/35085068
10.1016/j.biocel.2013.05.016
10.1371/journal.pone.0007934
10.1186/2044-5040-2-20
10.1016/j.cmet.2012.12.012
10.1038/s41598-018-26632-w
10.2337/diab.46.4.541
10.1016/j.cmet.2006.05.010
10.1016/j.cmet.2007.11.003
10.1074/jbc.M611214200
10.1074/jbc.M606742200
10.1111/febs.15070
10.1038/nature01705
10.1152/ajpendo.00477.2004
10.1002/jcsm.12145
10.1113/JP272039
10.1038/nm.2293
10.1074/jbc.274.8.5193
10.1152/japplphysiol.01231.2007
10.2337/db17-0826
10.2337/diabetes.54.2.402
10.1016/j.freeradbiomed.2010.12.005
10.1038/emboj.2011.292
10.1101/gad.1152204
10.18632/aging.100802
10.1113/jphysiol.2002.034223
10.1159/000365947
10.1074/jbc.M110.149328
10.2337/diabetes.53.4.1052
10.1042/bj3590639
10.14814/phy2.12462
10.1016/j.smim.2014.02.009
10.1016/j.tem.2011.12.008
10.1152/ajpendo.00512.2010
10.1016/j.cell.2007.08.047
10.1007/s00125-003-1196-3
10.1038/nm788
10.1152/ajpendo.00115.2014
10.1371/journal.pone.0100525
10.1016/j.tem.2012.06.008
10.1152/japplphysiol.00036.2003
10.1074/jbc.M200958200
10.1016/j.bbrc.2010.11.061
10.1016/j.mce.2006.03.017
10.1038/ncb1404
10.1038/nature00904
10.2337/db05-1322
10.1038/sj.ijo.0800476
10.1139/H09-047
10.1074/jbc.M205277200
10.1074/jbc.RA118.001801
10.1172/JCI110399
10.1038/nature07221
10.1073/pnas.0607795103
10.1038/s41467-019-12523-9
10.1074/jbc.M408862200
10.2337/diabetes.51.5.1477
10.1172/JCI39054
10.7326/0003-4819-147-6-200709180-00005
10.1016/j.tem.2015.02.009
10.1210/en.2005-0404
10.1074/jbc.M603038200
10.1074/jbc.M105945200
10.1111/j.1751-2980.2011.00525.x
10.1128/MCB.00685-09
10.2337/db19-0088
10.1210/en.2005-0850
10.1016/j.mce.2014.06.010
10.3389/fphys.2016.00411
10.1016/j.cmet.2005.05.004
10.2337/db12-1107
10.1074/jbc.M101087200
10.1056/NEJMoa012512
10.2337/diabetes.49.7.1092
10.1074/jbc.M312021200
10.1172/JCI114857
10.1152/japplphysiol.90668.2008
10.1073/pnas.1232352100
10.1152/ajpendo.00032.2001
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2020 by the authors. 2020
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Issue 18
Keywords exercise
type 2 diabetes
skeletal muscle
signal transduction
p38 MAPK
energy metabolism
Language English
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References LeBrasseur (ref_115) 2011; 300
Maekawa (ref_11) 2010; 30
Ji (ref_55) 2015; 61
Paul (ref_98) 2010; 191
Thayer (ref_6) 2000; 40
Ding (ref_97) 2017; 8
Klip (ref_95) 2009; 34
Antonescu (ref_43) 2005; 146
Boppart (ref_31) 2001; 280
Qin (ref_99) 2010; 403
Somwar (ref_45) 2002; 277
Kawamoto (ref_79) 2016; 4
Sabio (ref_7) 2014; 26
Yuasa (ref_104) 2018; 8
Mao (ref_89) 2006; 8
Talbot (ref_81) 2014; 393
Jing (ref_106) 2015; 62
Zetser (ref_39) 1999; 274
McKinsey (ref_58) 2000; 97
Lawan (ref_83) 2018; 67
Puigserver (ref_60) 1999; 286
Gehart (ref_72) 2010; 11
Gupta (ref_9) 1995; 267
Ciciliot (ref_4) 2013; 45
Yamauchi (ref_86) 2002; 8
Thong (ref_93) 2003; 94
ref_26
Teruel (ref_73) 2004; 279
Mayr (ref_16) 2001; 2
Izumiya (ref_114) 2008; 7
Odeh (ref_102) 2020; 287
Summermatter (ref_57) 2013; 110
Dokken (ref_75) 2008; 294
Sylow (ref_49) 2016; 594
Zhou (ref_24) 2011; 17
Sayeed (ref_90) 2018; 293
Barger (ref_21) 2001; 276
Handschin (ref_113) 2007; 117
Zhang (ref_100) 2011; 30
Keren (ref_30) 2006; 252
Baar (ref_53) 2002; 16
Knutti (ref_61) 2001; 98
Yu (ref_33) 2003; 546
Crunkhorn (ref_78) 2007; 282
Ishiki (ref_94) 2005; 146
Bost (ref_85) 2005; 54
Roth (ref_84) 2009; 119
Lin (ref_63) 2002; 418
Pospisilik (ref_116) 2007; 131
Daugaard (ref_82) 2000; 49
Fujishiro (ref_46) 2001; 276
Herzig (ref_18) 2001; 413
Cao (ref_10) 2005; 280
Lee (ref_25) 2011; 17
Zhang (ref_101) 2012; 2
Sigal (ref_29) 2007; 147
Somwar (ref_92) 2001; 359
Neufer (ref_69) 2012; 23
Collins (ref_17) 2006; 281
Yu (ref_70) 2002; 277
James (ref_108) 2012; 23
Koh (ref_111) 2019; 68
DeFronzo (ref_2) 1981; 68
Parker (ref_91) 2016; 7
Wu (ref_22) 2006; 4
Ribe (ref_44) 2005; 146
Brunmair (ref_117) 2004; 53
Olofsson (ref_13) 2008; 93
Lin (ref_52) 2005; 1
Papaconstantinou (ref_103) 2015; 7
Foster (ref_66) 2012; 45
Geiger (ref_47) 2005; 288
Kim (ref_48) 2011; 286
Coffey (ref_32) 2006; 20
Kuma (ref_19) 2004; 379
Yamauchi (ref_87) 2003; 423
Calvo (ref_54) 2008; 104
Archuleta (ref_77) 2009; 47
ref_65
Bonnard (ref_109) 2008; 118
Bonen (ref_68) 2004; 18
Holloszy (ref_110) 2013; 62
Kim (ref_37) 2016; 228
Akimoto (ref_56) 2005; 280
Knudsen (ref_50) 2019; 10
McGee (ref_41) 2004; 53
Henriksen (ref_71) 2011; 51
Somwar (ref_42) 2000; 49
Qiao (ref_15) 2006; 281
ref_118
Chambers (ref_35) 2009; 587
Fan (ref_8) 2004; 18
Yang (ref_14) 2005; 280
Lawrence (ref_20) 1997; 46
Feng (ref_105) 2011; 12
Kriketos (ref_5) 1997; 21
Foretz (ref_96) 2014; 20
Koistinen (ref_76) 2003; 46
Xiong (ref_23) 2007; 282
Ho (ref_51) 2004; 286
Lemieux (ref_38) 2003; 17
Yoon (ref_88) 2006; 55
Hegarty (ref_107) 2002; 51
Tseng (ref_12) 2008; 454
Wu (ref_59) 2001; 20
Meyer (ref_67) 2002; 282
Sandri (ref_112) 2006; 103
Zurlo (ref_1) 1990; 86
Egan (ref_28) 2013; 17
Handschin (ref_64) 2003; 100
Kim (ref_74) 2008; 105
Combes (ref_36) 2015; 3
Richter (ref_3) 2013; 93
Zhao (ref_40) 1999; 19
Puigserver (ref_62) 2001; 8
Brown (ref_80) 2015; 308
Mounier (ref_34) 2015; 26
Borst (ref_27) 2004; 33
References_xml – volume: 17
  start-page: 1658
  year: 2003
  ident: ref_38
  article-title: The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  contributor:
    fullname: Lemieux
– volume: 93
  start-page: 4880
  year: 2008
  ident: ref_13
  article-title: CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2008-0574
  contributor:
    fullname: Olofsson
– volume: 62
  start-page: 1319
  year: 2015
  ident: ref_106
  article-title: Hepatic p38alpha regulates gluconeogenesis by suppressing AMPK
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2014.12.032
  contributor:
    fullname: Jing
– volume: 93
  start-page: 993
  year: 2013
  ident: ref_3
  article-title: Exercise, GLUT4, and skeletal muscle glucose uptake
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00038.2012
  contributor:
    fullname: Richter
– volume: 280
  start-page: 42731
  year: 2005
  ident: ref_10
  article-title: p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M506223200
  contributor:
    fullname: Cao
– volume: 18
  start-page: 1144
  year: 2004
  ident: ref_68
  article-title: Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  contributor:
    fullname: Bonen
– volume: 191
  start-page: 1395
  year: 2010
  ident: ref_98
  article-title: Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201006098
  contributor:
    fullname: Paul
– volume: 294
  start-page: E615
  year: 2008
  ident: ref_75
  article-title: Oxidative stress-induced insulin resistance in rat skeletal muscle: Role of glycogen synthase kinase-3
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00578.2007
  contributor:
    fullname: Dokken
– volume: 4
  start-page: e12876
  year: 2016
  ident: ref_79
  article-title: Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.12876
  contributor:
    fullname: Kawamoto
– volume: 286
  start-page: R342
  year: 2004
  ident: ref_51
  article-title: p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00563.2003
  contributor:
    fullname: Ho
– volume: 20
  start-page: 953
  year: 2014
  ident: ref_96
  article-title: Metformin: From mechanisms of action to therapies
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.09.018
  contributor:
    fullname: Foretz
– volume: 45
  start-page: 266
  year: 2012
  ident: ref_66
  article-title: p38gamma activity is required for maintenance of slow skeletal muscle size
  publication-title: Muscle Nerve
  doi: 10.1002/mus.22289
  contributor:
    fullname: Foster
– volume: 286
  start-page: 1368
  year: 1999
  ident: ref_60
  article-title: Activation of PPARgamma coactivator-1 through transcription factor docking
  publication-title: Science
  doi: 10.1126/science.286.5443.1368
  contributor:
    fullname: Puigserver
– volume: 33
  start-page: 548
  year: 2004
  ident: ref_27
  article-title: Interventions for sarcopenia and muscle weakness in older people
  publication-title: Age Ageing
  doi: 10.1093/ageing/afh201
  contributor:
    fullname: Borst
– volume: 413
  start-page: 179
  year: 2001
  ident: ref_18
  article-title: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
  publication-title: Nature
  doi: 10.1038/35093131
  contributor:
    fullname: Herzig
– volume: 20
  start-page: 6414
  year: 2001
  ident: ref_59
  article-title: Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
  publication-title: EMBO J.
  doi: 10.1093/emboj/20.22.6414
  contributor:
    fullname: Wu
– volume: 20
  start-page: 190
  year: 2006
  ident: ref_32
  article-title: Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  contributor:
    fullname: Coffey
– volume: 97
  start-page: 14400
  year: 2000
  ident: ref_58
  article-title: Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.260501497
  contributor:
    fullname: McKinsey
– volume: 8
  start-page: 971
  year: 2001
  ident: ref_62
  article-title: Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(01)00390-2
  contributor:
    fullname: Puigserver
– volume: 228
  start-page: 105
  year: 2016
  ident: ref_37
  article-title: AMPK, a metabolic sensor, is involved in isoeugenol-induced glucose uptake in muscle cells
  publication-title: J. Endocrinol.
  doi: 10.1530/JOE-15-0302
  contributor:
    fullname: Kim
– volume: 19
  start-page: 21
  year: 1999
  ident: ref_40
  article-title: Regulation of the MEF2 family of transcription factors by p38
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.19.1.21
  contributor:
    fullname: Zhao
– volume: 17
  start-page: 1251
  year: 2011
  ident: ref_25
  article-title: p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis
  publication-title: Nat. Med.
  doi: 10.1038/nm.2449
  contributor:
    fullname: Lee
– volume: 587
  start-page: 3363
  year: 2009
  ident: ref_35
  article-title: Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.165639
  contributor:
    fullname: Chambers
– volume: 146
  start-page: 1713
  year: 2005
  ident: ref_44
  article-title: Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580
  publication-title: Endocrinology
  doi: 10.1210/en.2004-1294
  contributor:
    fullname: Ribe
– volume: 267
  start-page: 389
  year: 1995
  ident: ref_9
  article-title: Transcription factor ATF2 regulation by the JNK signal transduction pathway
  publication-title: Science
  doi: 10.1126/science.7824938
  contributor:
    fullname: Gupta
– volume: 110
  start-page: 20314
  year: 2013
  ident: ref_57
  article-title: The transcriptional coactivator PGC-1alpha is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1312039110
  contributor:
    fullname: Summermatter
– volume: 47
  start-page: 1486
  year: 2009
  ident: ref_77
  article-title: Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: Role of p38 MAPK
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2009.08.014
  contributor:
    fullname: Archuleta
– volume: 49
  start-page: 1794
  year: 2000
  ident: ref_42
  article-title: Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: Potential role in the stimulation of glucose transport
  publication-title: Diabetes
  doi: 10.2337/diabetes.49.11.1794
  contributor:
    fullname: Somwar
– volume: 379
  start-page: 133
  year: 2004
  ident: ref_19
  article-title: Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta
  publication-title: Biochem. J.
  doi: 10.1042/bj20031559
  contributor:
    fullname: Kuma
– volume: 280
  start-page: 38689
  year: 2005
  ident: ref_14
  article-title: Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M503486200
  contributor:
    fullname: Yang
– volume: 53
  start-page: 1208
  year: 2004
  ident: ref_41
  article-title: Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle
  publication-title: Diabetes
  doi: 10.2337/diabetes.53.5.1208
  contributor:
    fullname: McGee
– volume: 117
  start-page: 3463
  year: 2007
  ident: ref_113
  article-title: Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI31785
  contributor:
    fullname: Handschin
– volume: 281
  start-page: 24336
  year: 2006
  ident: ref_17
  article-title: p38 Mitogen-activated protein kinase mediates free fatty acid-induced gluconeogenesis in hepatocytes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M602177200
  contributor:
    fullname: Collins
– volume: 280
  start-page: C352
  year: 2001
  ident: ref_31
  article-title: Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.2001.280.2.C352
  contributor:
    fullname: Boppart
– volume: 98
  start-page: 9713
  year: 2001
  ident: ref_61
  article-title: Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.171184698
  contributor:
    fullname: Knutti
– volume: 11
  start-page: 834
  year: 2010
  ident: ref_72
  article-title: MAPK signalling in cellular metabolism: Stress or wellness?
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2010.160
  contributor:
    fullname: Gehart
– volume: 2
  start-page: 599
  year: 2001
  ident: ref_16
  article-title: Transcriptional regulation by the phosphorylation-dependent factor CREB
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/35085068
  contributor:
    fullname: Mayr
– volume: 45
  start-page: 2191
  year: 2013
  ident: ref_4
  article-title: Muscle type and fiber type specificity in muscle wasting
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2013.05.016
  contributor:
    fullname: Ciciliot
– ident: ref_65
  doi: 10.1371/journal.pone.0007934
– volume: 2
  start-page: 20
  year: 2012
  ident: ref_101
  article-title: p38beta MAPK upregulates atrogin1/MAFbx by specific phosphorylation of C/EBPbeta
  publication-title: Skelet. Muscle
  doi: 10.1186/2044-5040-2-20
  contributor:
    fullname: Zhang
– volume: 17
  start-page: 162
  year: 2013
  ident: ref_28
  article-title: Exercise metabolism and the molecular regulation of skeletal muscle adaptation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.12.012
  contributor:
    fullname: Egan
– volume: 8
  start-page: 9037
  year: 2018
  ident: ref_104
  article-title: Targeted ablation of p38alpha MAPK suppresses denervation-induced muscle atrophy
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-26632-w
  contributor:
    fullname: Yuasa
– volume: 46
  start-page: 541
  year: 1997
  ident: ref_20
  article-title: New insights into the role and mechanism of glycogen synthase activation by insulin
  publication-title: Diabetes
  doi: 10.2337/diab.46.4.541
  contributor:
    fullname: Lawrence
– volume: 4
  start-page: 61
  year: 2006
  ident: ref_22
  article-title: Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2006.05.010
  contributor:
    fullname: Wu
– volume: 7
  start-page: 159
  year: 2008
  ident: ref_114
  article-title: Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2007.11.003
  contributor:
    fullname: Izumiya
– volume: 282
  start-page: 15439
  year: 2007
  ident: ref_78
  article-title: Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: Potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M611214200
  contributor:
    fullname: Crunkhorn
– volume: 282
  start-page: 4975
  year: 2007
  ident: ref_23
  article-title: p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M606742200
  contributor:
    fullname: Xiong
– volume: 287
  start-page: 73
  year: 2020
  ident: ref_102
  article-title: P38alpha MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles
  publication-title: FEBS J.
  doi: 10.1111/febs.15070
  contributor:
    fullname: Odeh
– volume: 16
  start-page: 1879
  year: 2002
  ident: ref_53
  article-title: Adaptations of skeletal muscle to exercise: Rapid increase in the transcriptional coactivator PGC-1
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
  contributor:
    fullname: Baar
– volume: 423
  start-page: 762
  year: 2003
  ident: ref_87
  article-title: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
  publication-title: Nature
  doi: 10.1038/nature01705
  contributor:
    fullname: Yamauchi
– volume: 288
  start-page: E782
  year: 2005
  ident: ref_47
  article-title: Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00477.2004
  contributor:
    fullname: Geiger
– volume: 8
  start-page: 202
  year: 2017
  ident: ref_97
  article-title: Activin A induces skeletal muscle catabolism via p38beta mitogen-activated protein kinase
  publication-title: J. Cachexia Sarcopenia Muscle
  doi: 10.1002/jcsm.12145
  contributor:
    fullname: Ding
– volume: 594
  start-page: 4997
  year: 2016
  ident: ref_49
  article-title: Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice
  publication-title: J. Physiol.
  doi: 10.1113/JP272039
  contributor:
    fullname: Sylow
– volume: 17
  start-page: 356
  year: 2011
  ident: ref_24
  article-title: Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
  publication-title: Nat. Med.
  doi: 10.1038/nm.2293
  contributor:
    fullname: Zhou
– volume: 274
  start-page: 5193
  year: 1999
  ident: ref_39
  article-title: p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.8.5193
  contributor:
    fullname: Zetser
– volume: 104
  start-page: 1304
  year: 2008
  ident: ref_54
  article-title: Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.01231.2007
  contributor:
    fullname: Calvo
– volume: 67
  start-page: 624
  year: 2018
  ident: ref_83
  article-title: Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance
  publication-title: Diabetes
  doi: 10.2337/db17-0826
  contributor:
    fullname: Lawan
– volume: 54
  start-page: 402
  year: 2005
  ident: ref_85
  article-title: The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
  publication-title: Diabetes
  doi: 10.2337/diabetes.54.2.402
  contributor:
    fullname: Bost
– volume: 51
  start-page: 993
  year: 2011
  ident: ref_71
  article-title: Oxidative stress and the etiology of insulin resistance and type 2 diabetes
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2010.12.005
  contributor:
    fullname: Henriksen
– volume: 30
  start-page: 4323
  year: 2011
  ident: ref_100
  article-title: C/EBPbeta mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.292
  contributor:
    fullname: Zhang
– volume: 18
  start-page: 278
  year: 2004
  ident: ref_8
  article-title: Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: Modulation by p38 MAPK
  publication-title: Genes Dev.
  doi: 10.1101/gad.1152204
  contributor:
    fullname: Fan
– volume: 7
  start-page: 718
  year: 2015
  ident: ref_103
  article-title: Attenuation of p38alpha MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells
  publication-title: Aging
  doi: 10.18632/aging.100802
  contributor:
    fullname: Papaconstantinou
– volume: 546
  start-page: 327
  year: 2003
  ident: ref_33
  article-title: Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2002.034223
  contributor:
    fullname: Yu
– volume: 61
  start-page: 139
  year: 2015
  ident: ref_55
  article-title: Role of PGC-1alpha in sarcopenia: Etiology and potential intervention—A mini-review
  publication-title: Gerontology
  doi: 10.1159/000365947
  contributor:
    fullname: Ji
– volume: 286
  start-page: 7567
  year: 2011
  ident: ref_48
  article-title: The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.149328
  contributor:
    fullname: Kim
– volume: 53
  start-page: 1052
  year: 2004
  ident: ref_117
  article-title: Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
  publication-title: Diabetes
  doi: 10.2337/diabetes.53.4.1052
  contributor:
    fullname: Brunmair
– volume: 359
  start-page: 639
  year: 2001
  ident: ref_92
  article-title: GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: Potential activation of GLUT4 via p38 mitogen-activated protein kinase
  publication-title: Biochem. J.
  doi: 10.1042/bj3590639
  contributor:
    fullname: Somwar
– volume: 3
  start-page: e12462
  year: 2015
  ident: ref_36
  article-title: Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.12462
  contributor:
    fullname: Combes
– volume: 26
  start-page: 237
  year: 2014
  ident: ref_7
  article-title: TNF and MAP kinase signalling pathways
  publication-title: Semin. Immunol.
  doi: 10.1016/j.smim.2014.02.009
  contributor:
    fullname: Sabio
– volume: 23
  start-page: 142
  year: 2012
  ident: ref_69
  article-title: Linking mitochondrial bioenergetics to insulin resistance via redox biology
  publication-title: Trends Endocrinol. Metab. TEM
  doi: 10.1016/j.tem.2011.12.008
  contributor:
    fullname: Neufer
– volume: 300
  start-page: E3
  year: 2011
  ident: ref_115
  article-title: Metabolic benefits of resistance training and fast glycolytic skeletal muscle
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00512.2010
  contributor:
    fullname: LeBrasseur
– volume: 131
  start-page: 476
  year: 2007
  ident: ref_116
  article-title: Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
  publication-title: Cell
  doi: 10.1016/j.cell.2007.08.047
  contributor:
    fullname: Pospisilik
– volume: 46
  start-page: 1324
  year: 2003
  ident: ref_76
  article-title: Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients
  publication-title: Diabetologia
  doi: 10.1007/s00125-003-1196-3
  contributor:
    fullname: Koistinen
– volume: 8
  start-page: 1288
  year: 2002
  ident: ref_86
  article-title: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
  publication-title: Nat. Med.
  doi: 10.1038/nm788
  contributor:
    fullname: Yamauchi
– volume: 118
  start-page: 789
  year: 2008
  ident: ref_109
  article-title: Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
  publication-title: J. Clin. Investig.
  contributor:
    fullname: Bonnard
– volume: 40
  start-page: 284
  year: 2000
  ident: ref_6
  article-title: A decade of aerobic endurance training: Histological evidence for fibre type transformation
  publication-title: J. Sports Med. Phys. Fit.
  contributor:
    fullname: Thayer
– volume: 308
  start-page: E63
  year: 2015
  ident: ref_80
  article-title: p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00115.2014
  contributor:
    fullname: Brown
– ident: ref_118
  doi: 10.1371/journal.pone.0100525
– volume: 23
  start-page: 429
  year: 2012
  ident: ref_108
  article-title: Mitochondrial oxidative stress and the metabolic syndrome
  publication-title: Trends Endocrinol. Metab. TEM
  doi: 10.1016/j.tem.2012.06.008
  contributor:
    fullname: James
– volume: 94
  start-page: 2337
  year: 2003
  ident: ref_93
  article-title: Prior exercise increases basal and insulin-induced p38 mitogen-activated protein kinase phosphorylation in human skeletal muscle
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00036.2003
  contributor:
    fullname: Thong
– volume: 277
  start-page: 50230
  year: 2002
  ident: ref_70
  article-title: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M200958200
  contributor:
    fullname: Yu
– volume: 403
  start-page: 473
  year: 2010
  ident: ref_99
  article-title: Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1alpha
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2010.11.061
  contributor:
    fullname: Qin
– volume: 252
  start-page: 224
  year: 2006
  ident: ref_30
  article-title: The p38 MAPK signaling pathway: A major regulator of skeletal muscle development
  publication-title: Mol. Cell. Endocrinol.
  doi: 10.1016/j.mce.2006.03.017
  contributor:
    fullname: Keren
– volume: 8
  start-page: 516
  year: 2006
  ident: ref_89
  article-title: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1404
  contributor:
    fullname: Mao
– volume: 418
  start-page: 797
  year: 2002
  ident: ref_63
  article-title: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
  publication-title: Nature
  doi: 10.1038/nature00904
  contributor:
    fullname: Lin
– volume: 55
  start-page: 2562
  year: 2006
  ident: ref_88
  article-title: Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
  publication-title: Diabetes
  doi: 10.2337/db05-1322
  contributor:
    fullname: Yoon
– volume: 21
  start-page: 796
  year: 1997
  ident: ref_5
  article-title: Muscle fibre type composition in infant and adult populations and relationships with obesity
  publication-title: Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes.
  doi: 10.1038/sj.ijo.0800476
  contributor:
    fullname: Kriketos
– volume: 34
  start-page: 481
  year: 2009
  ident: ref_95
  article-title: The many ways to regulate glucose transporter 4
  publication-title: Appl. Physiol. Nutr. Metab.
  doi: 10.1139/H09-047
  contributor:
    fullname: Klip
– volume: 277
  start-page: 50386
  year: 2002
  ident: ref_45
  article-title: A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M205277200
  contributor:
    fullname: Somwar
– volume: 293
  start-page: 13509
  year: 2018
  ident: ref_90
  article-title: A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA118.001801
  contributor:
    fullname: Sayeed
– volume: 68
  start-page: 1468
  year: 1981
  ident: ref_2
  article-title: Synergistic interaction between exercise and insulin on peripheral glucose uptake
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI110399
  contributor:
    fullname: DeFronzo
– volume: 454
  start-page: 1000
  year: 2008
  ident: ref_12
  article-title: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
  publication-title: Nature
  doi: 10.1038/nature07221
  contributor:
    fullname: Tseng
– volume: 103
  start-page: 16260
  year: 2006
  ident: ref_112
  article-title: PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0607795103
  contributor:
    fullname: Sandri
– volume: 10
  start-page: 4623
  year: 2019
  ident: ref_50
  article-title: Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12523-9
  contributor:
    fullname: Knudsen
– volume: 280
  start-page: 19587
  year: 2005
  ident: ref_56
  article-title: Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M408862200
  contributor:
    fullname: Akimoto
– volume: 51
  start-page: 1477
  year: 2002
  ident: ref_107
  article-title: Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.5.1477
  contributor:
    fullname: Hegarty
– volume: 119
  start-page: 3817
  year: 2009
  ident: ref_84
  article-title: MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI39054
  contributor:
    fullname: Roth
– volume: 147
  start-page: 357
  year: 2007
  ident: ref_29
  article-title: Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: A randomized trial
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-147-6-200709180-00005
  contributor:
    fullname: Sigal
– volume: 26
  start-page: 275
  year: 2015
  ident: ref_34
  article-title: Expanding roles for AMPK in skeletal muscle plasticity
  publication-title: Trends Endocrinol. Metab. TEM
  doi: 10.1016/j.tem.2015.02.009
  contributor:
    fullname: Mounier
– volume: 146
  start-page: 3773
  year: 2005
  ident: ref_43
  article-title: Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity
  publication-title: Endocrinology
  doi: 10.1210/en.2005-0404
  contributor:
    fullname: Antonescu
– volume: 281
  start-page: 24390
  year: 2006
  ident: ref_15
  article-title: CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M603038200
  contributor:
    fullname: Qiao
– volume: 276
  start-page: 44495
  year: 2001
  ident: ref_21
  article-title: p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: A potential role in the cardiac metabolic stress response
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105945200
  contributor:
    fullname: Barger
– volume: 12
  start-page: 327
  year: 2011
  ident: ref_105
  article-title: The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease
  publication-title: J. Dig. Dis.
  doi: 10.1111/j.1751-2980.2011.00525.x
  contributor:
    fullname: Feng
– volume: 30
  start-page: 613
  year: 2010
  ident: ref_11
  article-title: The role of ATF-2 family transcription factors in adipocyte differentiation: Antiobesity effects of p38 inhibitors
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00685-09
  contributor:
    fullname: Maekawa
– volume: 68
  start-page: 1552
  year: 2019
  ident: ref_111
  article-title: TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle
  publication-title: Diabetes
  doi: 10.2337/db19-0088
  contributor:
    fullname: Koh
– volume: 146
  start-page: 5071
  year: 2005
  ident: ref_94
  article-title: Minireview: Recent developments in the regulation of glucose transporter-4 traffic: New signals, locations, and partners
  publication-title: Endocrinology
  doi: 10.1210/en.2005-0850
  contributor:
    fullname: Ishiki
– volume: 393
  start-page: 129
  year: 2014
  ident: ref_81
  article-title: Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
  publication-title: Mol. Cell. Endocrinol.
  doi: 10.1016/j.mce.2014.06.010
  contributor:
    fullname: Talbot
– volume: 7
  start-page: 411
  year: 2016
  ident: ref_91
  article-title: Acute High-Intensity Interval Exercise-Induced Redox Signaling Is Associated with Enhanced Insulin Sensitivity in Obese Middle-Aged Men
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2016.00411
  contributor:
    fullname: Parker
– volume: 1
  start-page: 361
  year: 2005
  ident: ref_52
  article-title: Metabolic control through the PGC-1 family of transcription coactivators
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2005.05.004
  contributor:
    fullname: Lin
– volume: 62
  start-page: 1036
  year: 2013
  ident: ref_110
  article-title: “Deficiency” of mitochondria in muscle does not cause insulin resistance
  publication-title: Diabetes
  doi: 10.2337/db12-1107
  contributor:
    fullname: Holloszy
– volume: 276
  start-page: 19800
  year: 2001
  ident: ref_46
  article-title: MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M101087200
  contributor:
    fullname: Fujishiro
– ident: ref_26
  doi: 10.1056/NEJMoa012512
– volume: 49
  start-page: 1092
  year: 2000
  ident: ref_82
  article-title: Fiber type-specific expression of GLUT4 in human skeletal muscle: Influence of exercise training
  publication-title: Diabetes
  doi: 10.2337/diabetes.49.7.1092
  contributor:
    fullname: Daugaard
– volume: 279
  start-page: 17070
  year: 2004
  ident: ref_73
  article-title: Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M312021200
  contributor:
    fullname: Teruel
– volume: 86
  start-page: 1423
  year: 1990
  ident: ref_1
  article-title: Skeletal muscle metabolism is a major determinant of resting energy expenditure
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI114857
  contributor:
    fullname: Zurlo
– volume: 105
  start-page: 1246
  year: 2008
  ident: ref_74
  article-title: Gene expression during inactivity-induced muscle atrophy: Effects of brief bouts of a forceful contraction countermeasure
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.90668.2008
  contributor:
    fullname: Kim
– volume: 100
  start-page: 7111
  year: 2003
  ident: ref_64
  article-title: An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1232352100
  contributor:
    fullname: Handschin
– volume: 282
  start-page: E419
  year: 2002
  ident: ref_67
  article-title: Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00032.2001
  contributor:
    fullname: Meyer
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Snippet Skeletal muscles respond to environmental and physiological changes by varying their size, fiber type, and metabolic properties. P38 mitogen-activated protein...
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SubjectTerms Adaptation
Animals
Biological Transport
Carbohydrate Metabolism
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Energy
energy metabolism
Enzymes
Exercise
Gene expression
Glucose
Glucose - metabolism
Glucose Intolerance - metabolism
Glucose tolerance
Homeostasis
Humans
Insulin
Insulin - metabolism
Insulin resistance
Insulin Resistance - physiology
Intolerance
Kinases
Lipids
Liver
MAP kinase
Metabolic disorders
Metabolic syndrome
Metabolism
Mitochondria
Muscle contraction
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Obesity
Obesity - metabolism
Oxidation resistance
Oxidative metabolism
p38 MAPK
p38 Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - physiology
Phosphorylation
Physical fitness
Protein kinase
Proteins
Review
signal transduction
Signal Transduction - physiology
Skeletal muscle
Transcription factors
type 2 diabetes
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Title p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?
URI https://www.ncbi.nlm.nih.gov/pubmed/32899870
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https://search.proquest.com/docview/2441278201
https://pubmed.ncbi.nlm.nih.gov/PMC7555282
https://doaj.org/article/d858107768ee43a5a9fb2ddd7bdc76dd
Volume 21
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