Squamous Cell Papilloma of the Esophagus: A Case Series Highlighting Endoscopic and Histologic Features

Esophageal squamous papillomas are rare epithelial lesions typically discovered incidentally during EGD. Their prevalence is estimated to be less than 0.01% in the general population. We present three cases of esophageal squamous papillomas identified histologically. It may be possible to identify t...

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Bibliographic Details
Published inCase reports in gastrointestinal medicine Vol. 2020; no. 2020; pp. 1 - 4
Main Authors Uhlenhopp, Dustin J., Sunkara, Tagore, Olson, Kristin M.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2020
Hindawi
Hindawi Limited
Wiley
Subjects
Biopsy
Case reports
Case Series
Development and progression
Dysphagia
Endoscopy
Esophagus
Gastroenterology
Gastroesophageal reflux
Human papillomavirus
Ostomy
Pantoprazole
Papillomavirus infections
Patients
Squamous cell carcinoma
Tumors
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Summary:Esophageal squamous papillomas are rare epithelial lesions typically discovered incidentally during EGD. Their prevalence is estimated to be less than 0.01% in the general population. We present three cases of esophageal squamous papillomas identified histologically. It may be possible to identify these lesions macroscopically. One study provided a positive predictive value of 88% for squamous papilloma utilizing the triad of exophytic growth, wart-like projections, and surface vessel crossing seen on narrow band imaging during endoscopy. The etiology is unclear. Chronic mucosal irritation from GERD or esophagitis is the prevailing theory of pathogenesis, but HPV has been detected in some lesions. The malignant potential of these lesions is considered controversial. There are documented cases demonstrating complications with squamous cell carcinoma, so we recommend removal of all esophageal squamous papillomas; however, the small absolute number of cases documented in the literature makes drawing any associations or conclusions between esophageal squamous papillomas and squamous cell carcinoma difficult. Further research is needed regarding treatment and surveillance. This case series helps contribute to the small but growing literature of this rare finding.
Bibliography:Academic Editor: Hideto Kawaratani
ISSN:2090-6528
2090-6536
DOI:10.1155/2020/7645926