Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population

• Published in: International journal of molecular sciences Vol. 19; no. 12; p. 3727
• Main Authors: Elizondo-Montemayor, Leticia, Mendoza-Lara, Gerardo, Gutierrez-DelBosque, Gustavo, Peschard-Franco, Mariana, Nieblas, Bianca, Garcia-Rivas, Gerardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2018; MDPI
• Subjects: Body composition; Body fat; Body mass index; Body size; Bone density; cardiovascular disease; Cardiovascular diseases; Children; Cholesterol; diet; Exercise; Fat-free body mass; Insulin; Insulin resistance; irisin; Lipids; Metabolic disorders; Metabolic syndrome; nutrition; Obesity; obesity, neonates; Parameters; pediatric; Pediatrics; Physical activity; Physical training; Plasma levels; Puberty; Review; Risk analysis; Risk factors; Teenagers; metabolic syndrome; cardiovascular disease; body composition; nutrition; children; obesity, neonates; diet; irisin; pediatric
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms19123727

Exercise-induced irisin, a recently discovered myokine, has been linked to insulin resistance, obesity, and other diseases in adults; however, information in children is scarce and contradictory. We analyzed the limited evidence of irisin's effects in children and adolescents, and its association with body composition, exercise training, cardiovascular risk factors, and metabolic diseases, as well as the results of dietetic interventions. Both positive and negative correlations between irisin concentrations and body mass index, fat mass, fat-free mass, and other anthropometric parameters were found. Likewise, contradictory evidence was shown associating irisin plasma levels with cardiovascular and metabolic parameters such as glucose, insulin resistance, and cholesterol and other lipid and fatty acid plasma levels in healthy children, as well as in those with obesity and the metabolic syndrome. Gender, puberty, and hormonal differences were also examined. Furthermore, important contradictory findings according to the type and duration of exercise and of dietetic interventions in healthy and unhealthy subjects were demonstrated. In addition, correlations between mother⁻infant relations and circulating irisin were also identified. This review discusses the potential role of irisin in health and disease in the pediatric population.