Cellular Senescence and Inflammaging in the Skin Microenvironment

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 3849
• Main Authors: Lee, Young In, Choi, Sooyeon, Roh, Won Seok, Lee, Ju Hee, Kim, Tae-Gyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.04.2021; MDPI
• Subjects: Aging; Autophagy; Cardiovascular diseases; Cell cycle; Chemokines; Circadian rhythm; Collagen; Connective tissue; Cyclin-dependent kinases; Cytokines; Diabetes mellitus; DNA damage; Fibroblasts; Gene expression; Genotype & phenotype; Immune system; inflammaging; Inflammation; Insulin-like growth factors; keratinocytes; Kinases; melanocytes; Microbiomes; Microenvironments; Particulate matter; Phenotypes; Proteins; Review; Senescence; Skin; Ultraviolet radiation; senescence; fibroblasts; inflammaging; melanocytes; skin; immune cells; keratinocytes
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms22083849

Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is called "inflammaging". Inflammaging is not only related with age-associated chronic systemic diseases such as cardiovascular disease and diabetes, but also skin aging. As the largest organ of the body, skin is continuously exposed to external stressors such as UV radiation, air particulate matter, and human microbiome. In this review article, we present mechanisms for accumulation of senescence cells in different compartments of the skin based on cell types, and their association with skin resident immune cells to describe changes in cutaneous immunity during the aging process.