Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

• Published in: International journal of molecular sciences Vol. 23; no. 2; p. 905
• Main Authors: Jang, Sunhee, Kwon, Eui-Jong, Lee, Jennifer Jooha
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.01.2022; MDPI
• Subjects: Animals; Antibodies; Antigens; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - etiology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - therapy; Biomarkers; Cartilage; Clinical Studies as Topic; Combined Modality Therapy; Cytokines; Disease; Disease Management; Disease Models, Animal; Disease Susceptibility - immunology; Epidemiology; Gene expression; Genomes; Humans; Immune System - cytology; Immune System - immunology; Immune System - metabolism; Inflammation; Lymphocytes; Molecular Diagnostic Techniques; Pathogenesis; Prognosis; Review; Rheumatoid arthritis; Risk factors; Roles; Transcription factors; Treatment Outcome; Tumor necrosis factor-TNF; epidemiology; pathogenesis; diagnosis; precision medicine; autoantibodies; rheumatoid arthritis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23020905

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.