Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (CO...

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Bibliographic Details
Published inVirulence Vol. 15; no. 1; p. 2316438
Main Authors Kirk, Natalie M, Liang, Yuying, Ly, Hinh
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.12.2024
Taylor & Francis Group
Subjects
animal models
coronaviruses
pathogenesis
pathology
Respiratory pathogens
Review
pathogenesis
animal models
coronaviruses
Respiratory pathogens
pathology
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Summary:Animal models that can replicate clinical and pathologic features of severe human coronavirus infections have been instrumental in the development of novel vaccines and therapeutics. The goal of this review is to summarize our current understanding of the pathogenesis of coronavirus disease 2019 (COVID-19) and the pathologic features that can be observed in several currently available animal models. Knowledge gained from studying these animal models of SARS-CoV-2 infection can help inform appropriate model selection for disease modelling as well as for vaccine and therapeutic developments.
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ISSN:2150-5594
2150-5608
2150-5608
DOI:10.1080/21505594.2024.2316438