Circulating tumor cell isolation and diagnostics: toward routine clinical use

From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating...

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Bibliographic Details
Published inCancer research Vol. 71; no. 18; pp. 5955 - 5960
Main Authors van de Stolpe, Anja, Pantel, Klaus, Sleijfer, Stefan, Terstappen, Leon W, den Toonder, Jaap M J
Format Journal Article Conference Proceeding
LanguageEnglish
Published United States 15.09.2011
Subjects
Humans
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - pathology
Neoplastic Cells, Circulating - pathology
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Summary:From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) diagnostics. CTCs, captured as "liquid biopsy" from blood, for counting and characterization using pathology and molecular assays, are expected to replace metastatic tissue biopsies to be used to predict drug response and resistance and to monitor therapy response and cancer recurrence. CTCs are highly heterogeneous; therefore, cancer type-specific isolation technologies, as well as complex clinical interpretation software, are required.
Bibliography:ObjectType-Conference-1
SourceType-Conference Papers & Proceedings-1
content type line 25
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-11-1254