Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

• Published in: International journal of molecular sciences Vol. 20; no. 8; p. 2042
• Main Authors: Kang, Hyunkoo, Kim, Hyunwoo, Lee, Sungmin, Youn, HyeSook, Youn, BuHyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2019; MDPI
• Subjects: Brain cancer; Breast cancer; Cell adhesion & migration; Enzymes; Epigenetics; Genes; Genotype & phenotype; Glucose; Hypoxia; Investigations; Kinases; Lung cancer; Metabolism; Metastasis; Mutation; Proteins; Review; Signal transduction; Stem cells; Transcription factors; Tumorigenesis; Tumors; cancer progression; metastasis; EMT; metabolic reprogramming

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra- and intracellular stimulants. Recently, it was reported that metabolic shifts control EMT progression and induce tumor aggr...