Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra- and intracellular stimulants. Recently, it was reported that metabolic shifts control EMT progression and induce tumor aggr...

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Published inInternational journal of molecular sciences Vol. 20; no. 8; p. 2042
Main Authors Kang, Hyunkoo, Kim, Hyunwoo, Lee, Sungmin, Youn, HyeSook, Youn, BuHyun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.04.2019
MDPI
Subjects
Brain cancer
Breast cancer
Cell adhesion & migration
Enzymes
Epigenetics
Genes
Genotype & phenotype
Glucose
Hypoxia
Investigations
Kinases
Lung cancer
Metabolism
Metastasis
Mutation
Proteins
Review
Signal transduction
Stem cells
Transcription factors
Tumorigenesis
Tumors
cancer progression
metastasis
EMT
metabolic reprogramming
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Summary:Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra- and intracellular stimulants. Recently, it was reported that metabolic shifts control EMT progression and induce tumor aggressiveness. In this review, we summarize the involvement of altered glucose, lipid, and amino acid metabolic enzyme expression and the underlying molecular mechanisms in EMT induction in tumor cells. Moreover, we propose that metabolic regulation through gene-specific or pharmacological inhibition may suppress EMT and this treatment strategy may be applied to prevent tumor progression and improve anti-tumor therapeutic efficacy. This review presents evidence for the importance of metabolic changes in tumor progression and emphasizes the need for further studies to better understand tumor metabolism.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20082042