Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells

• Published in: International journal of molecular sciences Vol. 23; no. 3; p. 1671
• Main Authors: Yeo, Dannel, Bastian, Althea, Strauss, Heidi, Saxena, Payal, Grimison, Peter, Rasko, John E J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.01.2022; MDPI
• Subjects: Adenocarcinoma; Antigens; biomarker; Biomarkers; Biomarkers, Tumor - blood; Biopsy; Cancer therapies; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - therapy; Cell culture; Chemotherapy; Diagnosis; Gene expression; Humans; liquid biopsy; Medical prognosis; Metastases; Metastasis; Neoplastic Cells, Circulating - metabolism; organoids; Pancreatic cancer; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - therapy; Patients; Prognosis; Review; screening; stem cell; Tumor cells; Tumors; screening; stem cell; organoids; precision medicine; biomarker; prognosis; liquid biopsy; personalized medicine
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23031671

Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type, characterized by a dismal prognosis due to late diagnosis, frequent metastases, and limited therapeutic response to standard chemotherapy. Circulating tumor cells (CTCs) are a rare subset of tumor cells found in the blood of cancer patients. CTCs has the potential utility for screening, early and definitive diagnosis, prognostic and predictive assessment, and offers the potential for personalized management. However, a gold-standard CTC detection and enrichment method remains elusive, hindering comprehensive comparisons between studies. In this review, we summarize data regarding the utility of CTCs at different stages of PDAC from early to metastatic disease and discuss the molecular profiling and culture of CTCs. The characterization of CTCs brings us closer to defining the specific CTC subpopulation responsible for metastasis with the potential to uncover new therapies and more effective management options for PDAC.